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ERG28 and CDK5RAP2
Number of citations of the paper that reports this interaction (PubMedID
16169070
)
0
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
ERG28
CDK5RAP2
Description
ergosterol biosynthesis 28 homolog
CDK5 regulatory subunit associated protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Membrane
Transport Vesicle
Pericentriolar Material
Spindle Pole
Gamma-tubulin Ring Complex
Cytoplasm
Golgi Apparatus
Centrosome
Microtubule Organizing Center
Cytosol
Cytoskeleton
Microtubule
Cell Junction
Microtubule Plus-end
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Mitotic Spindle Pole
Molecular Function
Protein Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Transcription Cis-regulatory Region Binding
Protein Binding
Calmodulin Binding
Microtubule Binding
Tubulin Binding
Protein Kinase Binding
Gamma-tubulin Binding
Protein-containing Complex Binding
Biological Process
Lipid Metabolic Process
Steroid Biosynthetic Process
Steroid Metabolic Process
Sterol Biosynthetic Process
Establishment Of Mitotic Spindle Orientation
Microtubule Cytoskeleton Organization
Microtubule Bundle Formation
Chromosome Segregation
Centrosome Cycle
Centriole Replication
Brain Development
Neurogenesis
Microtubule Organizing Center Organization
Positive Regulation Of Microtubule Polymerization
Regulation Of Neuron Differentiation
Negative Regulation Of Neuron Differentiation
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Centriole Replication
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Drugs
Diseases
Primary microcephaly (MCPH)
GWAS
Asthma (
27611488
)
Height (
28552196
)
Photic sneeze reflex (
27182965
)
Response to statin therapy (
20339536
)
Rheumatoid arthritis (
24782177
)
Interacting Genes
127 interacting genes:
ALDH2
ANXA1
ANXA7
AQP2
AQP3
AQP6
ARL13B
BAIAP2
BCL2L13
BID
BTBD2
CCDC106
CCL18
CD53
CD74
CDC42
CDK5RAP2
CELF3
CLDN5
CLDN7
CLN8
COX17
COXFA4L2
CRADD
CREB1
CREB3
CREB3L1
CSTF2
CYB561
DYNLL1
EBP
ELOVL4
ERBB2
ERBB3
ERBB4
ERGIC3
FAM174A
FAM209A
FAS
FCGR2B
FFAR2
FXR1
FXYD3
GADD45A
GET1
GJB5
GPR152
GPR37L1
GPR42
GPX8
GSK3B
HMGB1
HNRNPH3
HNRNPUL1
HSD17B11
HSPE1
HTR2C
HYLS1
JAGN1
KCNJ6
KLHL20
LHFPL5
LMNA
LSM2
LYPD5
MAPK8IP2
MGST3
MPHOSPH6
MRM1
MRPL38
MRPS12
MS4A3
MSMO1
MTERF3
MTNR1B
MUC1
NAT9
NCR3LG1
NDUFA3
NR1H2
NSDHL
NSF
PAFAH1B3
PCDHA4
PDZK1IP1
PEX2
PFN1
PHYHIP
PIGY
POLE2
POLR2C
POLR3F
PPP1R8
PQBP1
PSCA
RAB27A
REEP4
RETREG3
RPS6KA6
S100A8
SAR1A
SAT1
SEPHS1
SERPINB9
SGPL1
SLC10A6
SLC26A6
SLC34A2
SLC71A2
SNRPB
SNRPG
SSMEM1
STOM
STX1A
SULT1E1
TFG
TK1
TLCD4
TM4SF19
TMEM106A
TMEM222
TMEM31
TMPRSS2
TSC22D1
TTR
ZFP64
ZNF24
26 interacting genes:
ABCA2
CDK5
CDK5R1
CLIP4
CRMP1
EEF1G
ERG28
FBXO25
HAP1
KAT5
LRRK1
LUC7L2
MAGEH1
MAPRE1
NEFL
PCBD1
PTN
RBM48
REPS2
SENP2
STARD9
STK36
TBC1D4
TRIM37
TSNAX
ZPR1
Entrez ID
11161
55755
HPRD ID
05201
09740
Ensembl ID
ENSG00000133935
ENSG00000136861
Uniprot IDs
Q6FII3
Q86TW5
Q9UKR5
A0A0A0MRG9
A0A8I5KXG0
A0A8I5QKL1
B3KVI2
B9EG74
Q96SN8
PDB IDs
6X0V
8RX1
9G3Y
9G3Z
9G40
9H9P
Enriched GO Terms of Interacting Partners
?
Protein Binding
Membrane
Identical Protein Binding
Negative Regulation Of Apoptotic Process
Renal Water Transport
Negative Regulation Of Programmed Cell Death
Regulation Of Apoptotic Signaling Pathway
Polyol Transmembrane Transport
Regulation Of Apoptotic Process
Positive Regulation Of Cardiac Muscle Tissue Development
ERBB3:ERBB2 Complex
Regulation Of Secretion
Regulation Of Programmed Cell Death
Endoplasmic Reticulum Membrane
Regulation Of MAPK Cascade
Fluid Transport
Water Channel Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of Viral Entry Into Host Cell
Neuregulin Receptor Activity
Regulation Of Transport
Negative Regulation Of Hemopoiesis
Negative Regulation Of Secretion
Apolipoprotein A-I Receptor Binding
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Apoptotic Signaling Pathway
Negative Regulation Of Peptide Secretion
Apical Plasma Membrane
Positive Regulation Of Transport
Microtubule Cytoskeleton Organization
Growth Cone
Microtubule-based Process
Protein Kinase 5 Complex
Cytoskeleton Organization
Cerebellum Development
Establishment Of Organelle Localization
Perikaryon
Negative Regulation Of Motor Neuron Apoptotic Process
Hippocampus Development
Cell Projection Organization
ESC/E(Z) Complex
Regulation Of Motor Neuron Apoptotic Process
Neuromuscular Junction
Regulation Of Plasma Membrane Bounded Cell Projection Organization
Axon
Layer Formation In Cerebral Cortex
Plasma Membrane Bounded Cell Projection Organization
Regulation Of Cell Projection Organization
Regulation Of Neuron Projection Development
Cell Projection
Regulation Of Nervous System Development
Retrograde Axonal Transport
Attachment Of Mitotic Spindle Microtubules To Kinetochore
Microtubule Plus-end Binding
Microtubule Plus-end
Negative Regulation Of Cellular Component Organization
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Neuron Apoptotic Process
Organelle Localization
Regulation Of Microtubule-based Process
Regulation Of Intracellular Transport
Neuron Projection Regeneration
Diol Metabolic Process
Neuron Projection Development
Regulation Of Cellular Component Organization
Ionotropic Glutamate Receptor Binding
Spinal Cord Development
Endopeptidase Regulator Activity
Regulation Of Cellular Localization
Regulation Of Protein Targeting To Membrane
Regulation Of Synapse Organization
Organelle Organization
Negative Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter
Regulation Of Postsynapse Organization
Positive Regulation Of Presynaptic Cytosolic Calcium Concentration
Positive Regulation Of Microtubule Polymerization
DNA Endoreduplication
Pre-mRNA Catabolic Process
Positive Regulation Of Neurotrophin Production
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