RAB27A and SYTL4

Number of citations of the paper that reports this interaction (PMID 11865063)
48

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		RAB27A	SYTL4
Gene Name		RAB27A, member RAS oncogene family	synaptotagmin-like 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Lysosome Late Endosome Golgi Apparatus Apical Plasma Membrane Secretory Granule Dendrite Secretory Granule Membrane Multivesicular Body Membrane Melanosome Extracellular Vesicular Exosome Exocytic Vesicle	Nucleoplasm Cytoplasm Endosome Centrosome Plasma Membrane Synaptic Vesicle Extrinsic Component Of Membrane Secretory Granule Transport Vesicle Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding Myosin V Binding	Transporter Activity Phospholipid Binding Zinc Ion Binding Rab GTPase Binding Neurexin Family Protein Binding
	Biological Process	Protein Targeting Intracellular Protein Transport Exocytosis Vesicle Docking Involved In Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Rab Protein Signal Transduction Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Cellular Protein Metabolic Process Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Intracellular Protein Transport Exocytosis Positive Regulation Of Exocytosis Negative Regulation Of Insulin Secretion Positive Regulation Of Protein Secretion Multivesicular Body Sorting Pathway
Pathways		Peptide hormone metabolism Insulin processing
Drugs
Diseases
GWAS
Protein-Protein Interactions		28 interactors: ADRB2 APP C14orf1 COPS6 EEF1A1 EXPH5 GDF9 GDI1 GZMB KIAA1377 LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	12 interactors: CCDC85B CEP70 FXR2 HMG20A INS RAB27A RAB27B RAB3A RAB8A STX1A STXBP1 ZBTB7B
Entrez ID		5873	94121
HPRD ID		04845	06735
Ensembl ID		ENSG00000069974	ENSG00000102362
Uniprot IDs		A2RU94 P51159	A8K973 B2R7R4 Q71SF7 Q96C24
PDB IDs			2CSZ 3FDW
Enriched GO Terms of Interacting Partners?		Exocytosis Secretion By Cell Intracellular Transport Secretion Cellular Protein Localization Establishment Of Localization In Cell Cellular Localization Protein Transport Intracellular Protein Transport Establishment Of Protein Localization Protein Localization Vesicle-mediated Transport Regulation Of Secretion Regulation Of Cellular Localization Regulation Of Exocytosis Positive Regulation Of Secretion Transport Positive Regulation Of Exocytosis Positive Regulation Of Transport Regulation Of Vesicle-mediated Transport Regulation Of Establishment Of Protein Localization Multivesicular Body Sorting Pathway Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Protein Localization Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Protein Transport Positive Regulation Of Protein Secretion Regulation Of Protein Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Vesicle Localization Regulation Of Postsynaptic Membrane Potential Regulation Of Inhibitory Postsynaptic Membrane Potential Regulation Of Hormone Secretion Neurotransmitter Secretion Regulation Of Signaling Membrane Depolarization Glutamate Secretion Positive Regulation Of Protein Transport Regulation Of Neurotransmitter Levels Membrane Hyperpolarization Melanocyte Differentiation Neurotransmitter Transport Melanosome Localization Visual Perception Sensory Perception Of Light Stimulus Insulin Secretion Organelle Localization	Vesicle Docking Involved In Exocytosis Vesicle Docking Membrane Docking Regulation Of Exocytosis Positive Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Transport Establishment Of Organelle Localization Positive Regulation Of Secretion Exocytosis Regulation Of Secretion Regulation Of Vesicle-mediated Transport Rab Protein Signal Transduction Organelle Localization Secretion By Cell Regulation Of Cellular Localization Neurotransmitter Secretion Glutamate Secretion Secretion Protein Secretion Regulation Of Synaptic Vesicle Exocytosis Regulation Of Neurotransmitter Levels Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Positive Regulation Of Transport Regulation Of Synaptic Vesicle Transport Neurotransmitter Transport Multivesicular Body Sorting Pathway Cell-cell Signaling Synaptic Vesicle Exocytosis Vesicle Organization Acid Secretion Ras Protein Signal Transduction Regulation Of Neurotransmitter Secretion Synaptic Transmission Regulation Of Synaptic Vesicle Priming Dicarboxylic Acid Transport Regulation Of Synaptic Transmission Synaptic Vesicle Maturation Cellular Protein Localization Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Energy Reserve Metabolic Process Positive Regulation Of Regulated Secretory Pathway Intracellular Protein Transport Neuromuscular Synaptic Transmission Amino Acid Transport Regulation Of Synaptic Plasticity Melanosome Transport
Tagcloud ?		adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle	acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e plscr4 profoundly saponin slc27a3 triglycerides vldlr
Tagcloud (Difference) ?		adenocarcinoma aggressive benign cancerous carcinomas deadly ductal exosome gtpases hypothesized immunohistochemistry implicated invasion invasive malignancies member microarray microenvironment modulating pancreatic pdac regulating represent secretion tissues tp53 trafficking vesicle	acot2 adiponectin anxa2 asah3l atherogenic brought carry cyp7a1 enpp6 ginseng ginsenosides hfd hmgcs1 il1rn insig1 korean krge lipa mogat1 obesity osbpl3 physiology pla2g4e plscr4 profoundly saponin slc27a3 triglycerides vldlr
Tagcloud (Intersection) ?