RAB27A and SYTL1

Number of citations of the paper that reports this interaction (PubMedID 11980908)
0

Data Source:
HPRD (in vitro, in vivo)

		RAB27A	SYTL1
Description		RAB27A, member RAS oncogene family	synaptotagmin like 1
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Plasma Membrane Membrane Microvillus Membrane Melanosome Extracellular Exosome Exocytic Vesicle
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Protein Binding Small GTPase Binding Neurexin Family Protein Binding
	Biological Process	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Intracellular Protein Transport Exocytosis
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation	TBC/RABGAPs
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)
Interacting Genes		28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	7 interacting genes: AKT1 NCF1 NCF2 NRXN1 RAB27A RAB27B RAB8A
Entrez ID		5873	84958
HPRD ID		04845	12156
Ensembl ID		ENSG00000069974	ENSG00000142765
Uniprot IDs		A2RU94 P51159	Q8IYJ3
PDB IDs		6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region	Myosin V Binding Establishment Of Protein Localization Protein Localization To Synapse Phagolysosome GDP Binding Protein Localization To Cell Junction Superoxide-generating NADPH Oxidase Activator Activity Superoxide-generating NAD(P)H Oxidase Activity Secretion By Cell NADPH Oxidase Complex Trans-Golgi Network Transport Vesicle Vesicle-mediated Transport Secretion Localization Within Membrane Respiratory Burst Superoxide Anion Generation Phosphatidylinositol-3,4-bisphosphate Binding Exocytosis Multivesicular Body Membrane Exocytic Vesicle Establishment Of Protein Localization To Membrane Cellular Localization Establishment Of Localization In Cell Superoxide Metabolic Process Multivesicular Body Sorting Pathway Receptor Localization To Synapse Cellular Defense Response Protein Localization To Membrane Intracellular Protein Localization GTPase Activity Establishment Of Protein Localization To Plasma Membrane Electron Transfer Activity Protein Localization To Cilium Positive Regulation Of Protein Localization To Plasma Membrane Cellular Response To Calcium Ion Regulation Of TRNA Methylation GTP Binding Neuronal Cell Body Cytotoxic T Cell Degranulation Positive Regulation Of Constitutive Secretory Pathway G Protein Activity Positive Regulation Of Presynaptic Active Zone Assembly Positive Regulation Of Presynapse Assembly Positive Regulation Of CAMP-mediated Signaling Protein-containing Complex Assembly Involved In Synapse Maturation Positive Regulation Of Protein Localization To Cell Periphery Protein Transport Positive Regulation Of Exocytosis Positive Regulation Of Protein Localization To Membrane Vesicle-mediated Transport In Synapse
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