C14orf1 and CRADD

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		C14orf1	CRADD
Gene Name		chromosome 14 open reading frame 1	CASP2 and RIPK1 domain containing adaptor with death domain
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane Transport Vesicle	Nucleus Cytoplasm
	Molecular Function	Molecular_function	Protease Binding Protein Binding Protein Binding, Bridging Death Domain Binding
	Biological Process	Biological_process Sterol Biosynthetic Process	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Mechanical Stimulus Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease (cognitive decline) ( 23535033) Height ( 18391951)
Protein-Protein Interactions		62 interactors: ALDH2 ANXA1 ANXA7 BAIAP2 BID BTBD2 CCDC106 CCL18 CDC42 CDK5RAP2 CELF3 CLN8 COX17 CRADD CREB1 CSTF2 DYNLL1 FAS FCGR2B FXR1 GADD45A GSK3B HMGB1 HNRNPH3 HNRNPUL1 HSPE1 HYLS1 KLHL20 LSM2 MAPK8IP2 MPHOSPH6 MRPL38 MRPS12 NAT9 NDUFA4L2 NR1H2 NSF PAFAH1B3 PCDHA4 PEX2 PFN1 PHYHIP POLE2 POLR2C POLR3F PPP1R8 PQBP1 RAB27A RPS6KA6 S100A8 SAT1 SEPHS1 SERPINB9 SNRPB SNRPG SULT1E1 TFG TK1 TSC22D1 TTR ZFP64 ZNF24	18 interactors: APP APPL2 BBS5 C14orf1 CASP2 CASP8 CCSER2 DCXR EEF1A1 IL9R KCTD9 KPNA1 LRIF1 PIDD1 RIPK1 SLC35A3 TRIM54 VTN
Entrez ID		11161	8738
HPRD ID		05201	04584
Ensembl ID			ENSG00000169372
Uniprot IDs		Q6FII3 Q86TW5 Q9UKR5	F5H7C2 P78560 Q53XL1
PDB IDs			2O71 2OF5 3CRD
Enriched GO Terms of Interacting Partners?		MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Splicing Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death MRNA Processing Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process MRNA Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Regulation Of Cysteine-type Endopeptidase Activity RNA Processing Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Endopeptidase Activity Regulation Of Apoptotic Process Positive Regulation Of Peptidase Activity Cellular Metabolic Process Regulation Of Cell Death Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Nucleobase-containing Compound Metabolic Process Anatomical Structure Development Response To Stress Regulation Of Catalytic Activity Zymogen Activation Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Apoptotic Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Response To External Stimulus Apoptotic Process Metabolic Process Programmed Cell Death Regulation Of Metabolic Process Regulation Of Cellular Component Organization Cell Death Death Cellular Response To Mechanical Stimulus DNA-templated Transcription, Termination System Development Regulation Of Endopeptidase Activity Immune Response Positive Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Regulation Of Proteolysis Positive Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Execution Phase Of Apoptosis Protein Processing Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Macrophage Differentiation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Apoptotic Process Regulation Of Necroptotic Process Positive Regulation Of Proteolysis Extrinsic Apoptotic Signaling Pathway Zymogen Activation Programmed Cell Death Cell Death Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Copper Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Sterol Metabolic Process Regulation Of Necrotic Cell Death Positive Regulation Of Endopeptidase Activity Copper Ion Homeostasis Suckling Behavior Regulation Of Protein Binding Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Oligomerization Mating Behavior Regulation Of Extrinsic Apoptotic Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cell Cycle Phase Transition Regulation Of Protein Metabolic Process Positive Regulation Of Myeloid Leukocyte Differentiation Mating Interleukin-9-mediated Signaling Pathway Regulation Of ATP:ADP Antiporter Activity Positive Regulation Of Apoptotic Process Steroid Metabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Programmed Cell Death Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Tagcloud ?			bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Difference) ?			bcap31 bcl2l13 bnipl card4 casp2 casp8 cd25 cd69 churg css defect eosinophil eosinophilia eosinophils exacerbation granuloma ikbkb ikbke immunophenotype intrinsic necrotizing proapoptotic pycard rel spontaneous strauss transcriptome vasculitis wondered
Tagcloud (Intersection) ?