RAB27A and RPH3A

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		RAB27A	RPH3A
Description		RAB27A, member RAS oncogene family	rabphilin 3A
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Region Lysosome Endosome Late Endosome Golgi Apparatus Cytosol Membrane Apical Plasma Membrane Secretory Granule Dendrite Multivesicular Body Membrane Weibel-Palade Body Melanosome Membrane Specific Granule Lumen Melanosome Extracellular Exosome Exocytic Vesicle	Plasma Membrane Synaptic Vesicle Membrane Extrinsic Component Of Membrane Secretory Granule Synaptic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex Cell Projection Neuron Projection Dendritic Spine Synapse Postsynaptic Membrane Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Protein Domain Specific Binding Myosin V Binding	Calcium Ion Binding Protein Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Zinc Ion Binding Lipid Binding Selenium Binding Small GTPase Binding Phosphate Ion Binding Protein-containing Complex Binding Metal Ion Binding Inositol 1,4,5 Trisphosphate Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Exocytosis Blood Coagulation Protein Secretion Positive Regulation Of Gene Expression Vesicle-mediated Transport Antigen Processing And Presentation Melanocyte Differentiation Melanosome Localization Melanosome Transport Multivesicular Body Organization Cytotoxic T Cell Degranulation Natural Killer Cell Degranulation Pigmentation Positive Regulation Of Exocytosis Synaptic Vesicle Transport Positive Regulation Of Phagocytosis Pigment Granule Localization Pigment Granule Transport Multivesicular Body Sorting Pathway Complement-dependent Cytotoxicity Positive Regulation Of Regulated Secretory Pathway Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Constitutive Secretory Pathway Exosomal Secretion	Intracellular Protein Transport Protein Transport Synaptic Vesicle Priming Positive Regulation Of Calcium Ion-dependent Exocytosis Spontaneous Neurotransmitter Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion
Pathways		Insulin processing Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Fractional exhaled nitric oxide levels ( 25431337) Glioma ( 30714141)	Alcohol consumption (max-drinks) ( 29460428) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Chloride levels ( 29403010) Coronary artery disease ( 32469254) Epilepsy ( 33913524) LDL cholesterol levels ( 32203549) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Low density lipoprotein cholesterol levels ( 29403010 32154731) Low HDL-cholesterol levels ( 31006500) Platelet count ( 22139419) Serum uric acid levels ( 32514006) Spleen volume ( 34128465) Urate levels ( 31578528)
Interacting Genes		28 interacting genes: ADRB2 APP CEP126 COPS6 EEF1A1 ERG28 EXPH5 GDF9 GDI1 GZMB LRIF1 MLPH MYO5A MYRIP RABGGTB RBM48 RIMS1 RIMS2 RPH3A RPH3AL STX1A SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 UNC13D ZBTB16	13 interacting genes: ADD2 CASK CFAP298 GCH1 MYO5A NRXN1 RAB15 RAB27A RAB27B RAB3A RAB3B RAB8A YWHAH
Entrez ID		5873	22895
HPRD ID		04845	15273
Ensembl ID		ENSG00000069974	ENSG00000089169
Uniprot IDs		A2RU94 P51159	Q9Y2J0
PDB IDs		6HUF 7OPP 7OPQ 7OPR 8P3G 8P3H 8P3I 8P3J 8P3K
Enriched GO Terms of Interacting Partners?		Small GTPase Binding Intracellular Transport Establishment Of Localization In Cell Secretion By Cell Exocytosis Intracellular Protein Transport Cellular Localization Protein Transport Exocytic Vesicle Vesicle-mediated Transport Neurexin Family Protein Binding Secretion Establishment Of Protein Localization Intracellular Protein Localization Regulation Of Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Exocytosis Modulation Of Excitatory Postsynaptic Potential Regulation Of Secretion By Cell Regulation Of Secretion Regulation Of Regulated Secretory Pathway Regulation Of Vesicle-mediated Transport Positive Regulation Of Secretion By Cell Vesicle Docking Involved In Exocytosis Melanosome Positive Regulation Of Secretion Synaptic Vesicle Docking Positive Regulation Of Regulated Secretory Pathway Regulation Of Nervous System Process Regulation Of Establishment Of Protein Localization Positive Regulation Of Calcium Ion-dependent Exocytosis Synaptic Vesicle Priming Vesicle Docking Regulation Of Transport Signal Release Organelle Localization By Membrane Tethering Organelle Localization Myosin Binding Positive Regulation Of Establishment Of Protein Localization Membrane Docking Regulation Of Hormone Levels Neurotransmitter Transport Synaptic Vesicle Exocytosis Calcium-ion Regulated Exocytosis Regulated Exocytosis Spontaneous Neurotransmitter Secretion Positive Regulation Of Inhibitory Postsynaptic Potential Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Transport Protein Localization To Extracellular Region	Myosin V Binding GTPase Activity GTP Binding Regulation Of Exocytosis Exocytosis Secretion By Cell Secretion Intracellular Protein Localization Establishment Of Protein Localization Vesicle GDP Binding Protein Transport Establishment Of Localization In Cell Positive Regulation Of Exocytosis Nucleotide Binding Vesicle Localization Regulation Of Vesicle-mediated Transport Regulation Of Regulated Secretory Pathway Regulation Of Secretion By Cell Regulation Of Secretion Positive Regulation Of Regulated Secretory Pathway Regulation Of Transport Protein Localization To Synapse Vesicle-mediated Transport Organelle Localization G Protein Activity Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Protein Localization To Cell Junction Synaptic Vesicle Clustering Vesicle-mediated Transport In Synapse Melanosome Secretory Granule Positive Regulation Of Secretion By Cell Establishment Of Vesicle Localization Trans-Golgi Network Transport Vesicle Positive Regulation Of Secretion Hydrolase Activity GTP-dependent Protein Binding Melanosome Transport Establishment Of Melanosome Localization Pigment Granule Transport Synaptic Vesicle Membrane Synaptic Vesicle Melanosome Localization Pigment Granule Localization Exocytic Vesicle Endosome Multivesicular Body Membrane Late Endosome
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