RCAN3 and EPS8

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		RCAN3	EPS8
Description		RCAN family member 3	EGFR pathway substrate 8, signaling adaptor
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Plasma Membrane Brush Border Cell Cortex Postsynaptic Density Membrane NMDA Selective Glutamate Receptor Complex Growth Cone Vesicle Stereocilium Stereocilium Bundle Stereocilium Tip Ruffle Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Troponin I Binding	Actin Binding Protein Binding Small GTPase Binding
	Biological Process	Anatomical Structure Morphogenesis Calcium-mediated Signaling	Rho Protein Signal Transduction Adult Locomotory Behavior Regulation Of Cell Shape Exit From Mitosis Rac Protein Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Filament Length Regulation Of Rho Protein Signal Transduction Dendritic Cell Migration Behavioral Response To Ethanol Barbed-end Actin Filament Capping Actin Filament Bundle Assembly Actin Crosslink Formation Actin Polymerization-dependent Cell Motility Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Ruffle Assembly Cellular Response To Leukemia Inhibitory Factor
Pathways		SARS-CoV-1 activates/modulates innate immune responses	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Male-pattern baldness ( 28196072)	Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913)
Interacting Genes		5 interacting genes: EPS8 TNNI3 TRIM23 UNC119 ZDHHC17	61 interacting genes: ABI1 ACTA1 ADAM22 AIMP2 ALDH7A1 ARMC1 BAIAP2 BCKDK BLOC1S6 BORCS6 BYSL C19orf25 C6orf141 C8orf33 CASK CBL CCDC85B CSNK2B CTNNA3 CXCL2 DNALI1 DVL1 EGFR GOLGA8EP GRB2 GULP1 HNRNPC HOOK2 INPP5J ITGB1 ITGB3 ITGB5 ITSN2 MAP1LC3B MAP3K11 MRPL20 MYO15A NACC2 NFKB2 PCM1 PROSER2 RCAN3 RFXAP RSPH14 RUNX1T1 SCRN3 SERPINA5 SF3B3 SHB SHC1 SLC27A4 SMARCE1 SOS1 SRC TDP2 TEX28 TPRN USP6NL XAGE2 XRCC6 ZZZ3
Entrez ID		11123	2059
HPRD ID		05792	02563
Ensembl ID		ENSG00000117602	ENSG00000151491
Uniprot IDs		Q9UKA8	B4E3T6 Q12929
PDB IDs			2E8M 7TZK
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Caveolin-mediated Endocytosis Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Cardiac Troponin Complex Troponin C Binding Troponin T Binding Negative Regulation Of Clathrin-dependent Endocytosis Synapse Protein-cysteine S-myristoyltransferase Activity Protein Transport Actin Polymerization-dependent Cell Motility Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Troponin Complex Cardiac Myofibril Regulation Of Caveolin-mediated Endocytosis Protein-cysteine S-stearoyltransferase Activity NMDA Selective Glutamate Receptor Complex Positive Regulation Of Protein Tyrosine Kinase Activity Behavioral Response To Ethanol Stereocilium Bundle Establishment Of Protein Localization Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Stereocilium Tip Exit From Mitosis Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Regulation Of Neurotrophin TRK Receptor Signaling Pathway Golgi-associated Vesicle Membrane Actin Binding Actin Filament-based Process Barbed-end Actin Filament Capping Actin-myosin Filament Sliding Regulation Of Clathrin-dependent Endocytosis Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity	Epidermal Growth Factor Receptor Signaling Pathway Filopodium ERBB Signaling Pathway Protein Tyrosine Kinase Activator Activity Supramolecular Fiber Organization Actin Filament Organization Symbiont Entry Into Host Cell Ephrin Receptor Binding Actin Filament Bundle Organization Actin Filament Bundle Assembly Shc-EGFR Complex Focal Adhesion Enzyme-linked Receptor Protein Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Phosphotyrosine Residue Binding Biological Process Involved In Interaction With Host Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process Schwann Cell Development Ruffle SH3 Domain Binding Cellular Response To Growth Factor Stimulus Cellular Response To Platelet-derived Growth Factor Stimulus Epidermal Growth Factor Binding ERBB2 Signaling Pathway Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Response To Platelet-derived Growth Factor Neuregulin Binding Integrin Complex C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Response To Growth Factor Wound Healing, Spreading Of Cells Response To Activity Neurotrophin TRKA Receptor Binding Endocytosis Insulin Receptor Signaling Pathway Integrin Binding Virus Receptor Activity Insulin-like Growth Factor Receptor Signaling Pathway Epidermal Growth Factor Receptor Binding Heterotypic Cell-cell Adhesion Actin-based Cell Projection Cellular Developmental Process Import Into Cell Schaffer Collateral - CA1 Synapse Ruffle Membrane Integrin-mediated Signaling Pathway Lamellipodium
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