RCAN3 and TNNI3

Number of citations of the paper that reports this interaction (PubMedID 16516408)
0

Data Source:
BioGRID (protein complementation assay)
HPRD (in vitro, two hybrid)

		RCAN3	TNNI3
Description		RCAN family member 3	troponin I3, cardiac type
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol Troponin Complex Myofibril Sarcomere Contractile Muscle Fiber Cardiac Myofibril Cardiac Troponin Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Phosphatase Binding Troponin I Binding	Actin Binding Protein Binding Calcium Channel Inhibitor Activity Protein Kinase Binding Protein Domain Specific Binding Troponin C Binding Troponin T Binding Calcium-dependent Protein Binding Actin Filament Binding
	Biological Process	Anatomical Structure Morphogenesis Calcium-mediated Signaling	Vasculogenesis Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Skeletal Muscle Contraction Intracellular Calcium Ion Homeostasis Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Striated Muscle Contraction Heart Development Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Muscle Filament Sliding Negative Regulation Of ATP-dependent Activity Ventricular Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction
Pathways		SARS-CoV-1 activates/modulates innate immune responses	Striated Muscle Contraction Ion homeostasis
Drugs			N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Diseases			Hypertrophic cardiomyopathy (HCM)
GWAS		Male-pattern baldness ( 28196072)	Monocyte count ( 32888494) Platelet count ( 32888494)
Interacting Genes		5 interacting genes: EPS8 TNNI3 TRIM23 UNC119 ZDHHC17	19 interacting genes: ACTA1 HSPB2 LYST MST1 PAPPA PKD2 PKD2L1 PRKCA PSMC5 RASSF10 RCAN3 SOX4 TNNC1 TNNC2 TNNI3K TNNT1 TNNT2 TRIM55 TRIM63
Entrez ID		11123	7137
HPRD ID		05792	11769
Ensembl ID		ENSG00000117602	ENSG00000129991
Uniprot IDs		Q9UKA8	P19429 Q6FGX2
PDB IDs			1J1D 1J1E 1LXF 1MXL 1OZS 2KGB 2KRD 2L1R 2MZP 2N7L 4Y99 5VLN 5W88 5WCL 6KN7 6KN8 6MV3 7JGI 7SC2 7SC3 7SUP 7SVC 7SWG 7SWI 7SXC 7SXD 7UH9 7UHA 7UTI 7UTL 8DZV 8FMM 8FMN 8FMO 8FMP 8FMQ 8FMR 8FMS 8FMT
Enriched GO Terms of Interacting Partners?		Lipoprotein Transport Regulation Of Systemic Arterial Blood Pressure By Ischemic Conditions Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Caveolin-mediated Endocytosis Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Cardiac Troponin Complex Troponin C Binding Troponin T Binding Negative Regulation Of Clathrin-dependent Endocytosis Synapse Protein-cysteine S-myristoyltransferase Activity Protein Transport Actin Polymerization-dependent Cell Motility Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Troponin Complex Cardiac Myofibril Regulation Of Caveolin-mediated Endocytosis Protein-cysteine S-stearoyltransferase Activity NMDA Selective Glutamate Receptor Complex Positive Regulation Of Protein Tyrosine Kinase Activity Behavioral Response To Ethanol Stereocilium Bundle Establishment Of Protein Localization Positive Regulation Of Ruffle Assembly Actin Crosslink Formation Stereocilium Tip Exit From Mitosis Negative Regulation Of ATP-dependent Activity Contractile Muscle Fiber Calcium Channel Inhibitor Activity Muscle Filament Sliding Regulation Of Neurotrophin TRK Receptor Signaling Pathway Golgi-associated Vesicle Membrane Actin Binding Actin Filament-based Process Barbed-end Actin Filament Capping Actin-myosin Filament Sliding Regulation Of Clathrin-dependent Endocytosis Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Protein-cysteine S-palmitoyltransferase Activity	Troponin Complex Regulation Of Muscle System Process Troponin I Binding Muscle Contraction Muscle System Process Regulation Of Muscle Contraction Regulation Of System Process Striated Muscle Contraction Cardiac Troponin Complex Skeletal Muscle Contraction Troponin T Binding Transition Between Fast And Slow Fiber Sarcomere Striated Muscle Thin Filament Response To Water Cytoskeletal Protein Binding Regulation Of Skeletal Muscle Adaptation System Process Contractile Muscle Fiber Tropomyosin Binding Actinin Binding Muscle Alpha-actinin Binding Muscle Filament Sliding Cation Channel Complex Actin-myosin Filament Sliding Spinal Cord Development Non-motile Cilium Monoatomic Cation Channel Activity Sodium Channel Activity Metanephric Cortical Collecting Duct Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Sodium Ion Transport Metanephric Cortex Development Metanephric Distal Tubule Development Regulation Of Muscle Filament Sliding Speed Actin-mediated Cell Contraction Cardiac Muscle Contraction Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Detection Of Chemical Stimulus Involved In Sensory Perception Of Sour Taste Sour Taste Receptor Activity Detection Of Mechanical Stimulus Ventricular Cardiac Muscle Tissue Morphogenesis Response To Mechanical Stimulus Ciliary Membrane Mast Cell Secretory Granule Organization Polycystin Complex Protein Homotetramerization Metanephric Smooth Muscle Tissue Development Mesenchyme Development
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