PLK4 and TEC

Number of citations of the paper that reports this interaction (PubMedID 11489907)
0

Data Source:
HPRD (two hybrid, in vivo)

		PLK4	TEC
Description		polo like kinase 4	tec protein tyrosine kinase
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GO Annotations	Cellular Component	XY Body Nucleus Nucleolus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cleavage Furrow Deuterosome Procentriole Procentriole Replication Complex	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Identical Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Centriole Replication Regulation Of Cell Cycle Process Positive Regulation Of Centriole Replication Cilium Assembly Trophoblast Giant Cell Differentiation De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling
Drugs		Fostamatinib	Fostamatinib Zanubrutinib
Diseases
GWAS			Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)
Interacting Genes		25 interacting genes: ACTR2 AIRIM ARR3 BTRC CHD3 CYLD DCAF1 DNAJB13 DRC4 ELOA MIR126 MTUS2 OSBPL3 PRDM16 SFN SMAD4 SPAG5 TAX1BP3 TEC TENT5B TENT5C TFIP11 TGFBR1 TRIM54 ZBTB39	37 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS
Entrez ID		10733	7006
HPRD ID		10387	02786
Ensembl ID		ENSG00000142731	ENSG00000135605
Uniprot IDs		O00444	P42680
PDB IDs		2N19 3COK 4JXF 4N7V 4N7Z 4N9J 4YUR 4YYP 5LHY 5LHZ 6N45 6N46 6W38 6W3I 6W3J 8XPG	2LUL
Enriched GO Terms of Interacting Partners?		Cytoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Centrosome Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Microtubule Negative Regulation Of Cell Population Proliferation Positive Regulation Of Extracellular Matrix Assembly Endothelial Cell Activation Poly(A) RNA Polymerase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process I-SMAD Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Positive Regulation Of T Cell Receptor Signaling Pathway Microtubule Binding Regulation Of Extracellular Matrix Assembly Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Microtubule-based Process Regulation Of Cytoskeleton Organization Activin Receptor Signaling Pathway Cardiac Epithelial To Mesenchymal Transition Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Centriolar Satellite Regulation Of Primary Metabolic Process Ciliary Basal Body Phosphoprotein Binding Negative Regulation Of Interleukin-18-mediated Signaling Pathway Regulation Of Wnt Signaling Pathway Met1-linked Polyubiquitin Deubiquitinase Activity Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cardiac Myofibril Assembly Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Neuron Fate Commitment Ventricular Septum Morphogenesis Nucleus Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Wnt Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process
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