PLK4 and TAX1BP3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		PLK4	TAX1BP3
Gene Name		polo-like kinase 4	Tax1 (human T-cell leukemia virus type I) binding protein 3
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Gene Ontology Annotations	Cellular Component	Nucleolus Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Nucleus Cytoplasm Plasma Membrane Actin Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Organelle Organization Centriole Replication Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation De Novo Centriole Assembly	Rho Protein Signal Transduction Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Activation Of Cdc42 GTPase Activity Negative Regulation Of Protein Localization To Cell Surface
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARR3 C1orf109 CHD3 FAM46C HDAC1 MTUS2 SFN SMAD4 TAX1BP3 TCEB3 TEC TGFBR1	14 interactors: ARNT2 CDK5RAP3 CNTN2 CTNNB1 DTX1 GATA1 GLS GLS2 PLK4 RNF183 RTKN STAU1 TCEA2 TRIM29
Entrez ID		10733	30851
HPRD ID		10387	18160
Ensembl ID		ENSG00000142731	ENSG00000213977
Uniprot IDs		O00444	O14907
PDB IDs		3COK	2KG2 2L4S 2L4T 2VZ5 3GJ9 3SFJ 4E3B
Enriched GO Terms of Interacting Partners?		Endothelial Cell Activation Regulation Of Cell Proliferation Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Cell Death Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Nucleocytoplasmic Transport Embryonic Morphogenesis Skin Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Protein Localization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of Epidermis Development Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of Viral Transcription Organ Morphogenesis RNA Metabolic Process Neuron Fate Commitment Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport	Glutamate Secretion Glutamine Metabolic Process Regulation Of Glycoprotein Biosynthetic Process Glial Cell Differentiation In Utero Embryonic Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Gliogenesis Regulation Of Neurogenesis Centrosome Cycle Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Neurogenesis Acid Secretion Establishment Of Protein Localization To Juxtaparanode Region Of Axon Brain Development Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Negative Regulation Of Cell Development Head Development Regulation Of Glial Cell Differentiation Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Development Positive Regulation Of Gene Expression RNA Biosynthetic Process Dicarboxylic Acid Transport Regulation Of Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Cell-cell Signaling Basophil Differentiation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Centriole Replication Positive Regulation Of Adenosine Receptor Signaling Pathway Schwann Cell Proliferation Eosinophil Fate Commitment Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Telencephalon Cell Migration Biosynthetic Process Centrosome Organization Forebrain Cell Migration Regulation Of Gliogenesis Central Nervous System Development Neurotransmitter Secretion Microtubule Cytoskeleton Organization Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Eosinophil Differentiation Clustering Of Voltage-gated Potassium Channels
Tagcloud ?		aspirates biologically biomarker characterize correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	anxa6 art atomic benchmarked biologically calu cdc42 differentially distinctive experimentally exploit feasibility identity integrating modeled modeling opposite pair pairs pipeline predictions proteomic ptbp1 solved splice splicing tasser translated variants
Tagcloud (Difference) ?		aspirates biomarker characterize correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	anxa6 art atomic benchmarked calu cdc42 differentially distinctive experimentally exploit feasibility identity integrating modeled modeling opposite pair pairs pipeline predictions proteomic ptbp1 solved splice splicing tasser translated variants
Tagcloud (Intersection) ?		biologically