PLK4 and FAM46C

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLK4	FAM46C
Gene Name		polo-like kinase 4	family with sequence similarity 46, member C
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleolus Centrosome Centriole Cytosol Cleavage Furrow Deuterosome
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Organelle Organization Centriole Replication Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation De Novo Centriole Assembly
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARR3 C1orf109 CHD3 FAM46C HDAC1 MTUS2 SFN SMAD4 TAX1BP3 TCEB3 TEC TGFBR1	7 interactors: AP2B1 DAZAP2 MVP PARK2 PLK4 RHOXF2 TRIP6
Entrez ID		10733	54855
HPRD ID		10387	13312
Ensembl ID		ENSG00000142731	ENSG00000183508
Uniprot IDs		O00444	Q5VWP2
PDB IDs		3COK
Enriched GO Terms of Interacting Partners?		Endothelial Cell Activation Regulation Of Cell Proliferation Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Cell Death Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Nucleocytoplasmic Transport Embryonic Morphogenesis Skin Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Protein Localization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of Epidermis Development Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of Viral Transcription Organ Morphogenesis RNA Metabolic Process Neuron Fate Commitment Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport	Negative Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Mitochondrial Fusion Positive Regulation Of Centriole Replication Positive Regulation Of Protein Linear Polyubiquitination ERBB Signaling Pathway Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Dopamine Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Manganese Ion Protein K27-linked Ubiquitination Protein K29-linked Ubiquitination Negative Regulation Of Mitochondrial Fusion Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Kinase Activity Positive Regulation Of Centrosome Duplication Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitochondrial Fusion Negative Regulation Of Glucokinase Activity Neuron Cellular Homeostasis Positive Regulation Of Oxidative Stress-induced Cell Death Protein K6-linked Ubiquitination Negative Regulation Of Oxidative Stress-induced Neuron Death Negative Regulation Of Signaling Positive Regulation Of Mitochondrial Fission Negative Regulation Of Transferase Activity Regulation Of Mitochondrion Degradation Negative Regulation Of Protein Phosphorylation Dopamine Transport Regulation Of Centriole Replication Aggresome Assembly Negative Regulation Of Protein Autophosphorylation Regulation Of Mitochondrial Fission Neurotransmitter Uptake Norepinephrine Metabolic Process De Novo Centriole Assembly Negative Regulation Of Actin Filament Bundle Assembly Synaptic Transmission, Dopaminergic Regulation Of Signaling Negative Regulation Of Phosphorylation Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Centriole Replication Positive Regulation Of Organelle Organization Zinc Ion Homeostasis Negative Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Release Of Cytochrome C From Mitochondria Response To Manganese Ion
Tagcloud ?		aspirates biologically biomarker characterize correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	additionally characterize cheap comprehensive constructed customized del17p demonstrates easy fast frequency insight landscape literature majority mm mutated mutational myeloma panel practical prevalence profile provides published sequencing targeted tp53 untreated
Tagcloud (Difference) ?		aspirates biologically biomarker correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	additionally cheap comprehensive constructed customized del17p demonstrates easy fast frequency insight landscape literature majority mm mutated mutational myeloma panel practical prevalence profile provides published sequencing targeted tp53 untreated
Tagcloud (Intersection) ?		characterize