PLK4 and TCEB3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		PLK4	TCEB3
Gene Name		polo-like kinase 4	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Centrosome Centriole Cytosol Cleavage Furrow Deuterosome	Extracellular Space Nucleus Nucleoplasm Cytoplasm Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding	DNA Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Protein Phosphorylation Organelle Organization Centriole Replication Positive Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation De Novo Centriole Assembly	Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Positive Regulation Of Viral Transcription
Pathways		Organelle biogenesis and maintenance Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes G2/M Transition Assembly of the primary cilium Centrosome maturation Regulation of PLK1 Activity at G2/M Transition Mitotic G2-G2/M phases Anchoring of the basal body to the plasma membrane Recruitment of mitotic centrosome proteins and complexes Cell Cycle, Mitotic	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ARR3 C1orf109 CHD3 FAM46C HDAC1 MTUS2 SFN SMAD4 TAX1BP3 TCEB3 TEC TGFBR1	21 interactors: BRCA1 CEP57L1 CEP70 FAM9B GMCL1 HOMEZ JAKMIP2 KRT40 KRTAP10-3 MDFI MED21 MID2 NINL PLK4 POLR2A RAD54B RAP1A REXO1 SPERT TCEB2 TRIM54
Entrez ID		10733	6924
HPRD ID		10387	02873
Ensembl ID		ENSG00000142731	ENSG00000011007
Uniprot IDs		O00444	Q14241
PDB IDs		3COK	4HFX
Enriched GO Terms of Interacting Partners?		Endothelial Cell Activation Regulation Of Cell Proliferation Positive Regulation Of SMAD Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Regulation Of SMAD Protein Import Into Nucleus Negative Regulation Of Cell Death Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Intracellular Protein Transport Transcription Initiation From RNA Polymerase II Promoter Cardiac Epithelial To Mesenchymal Transition Regulation Of Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Nucleocytoplasmic Transport Embryonic Morphogenesis Skin Development DNA-templated Transcription, Initiation Negative Regulation Of Cell Proliferation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Gene Expression Regulation Of Cell Death Regulation Of Protein Localization Positive Regulation Of Cellular Biosynthetic Process Regulation Of Pathway-restricted SMAD Protein Phosphorylation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Transport Negative Regulation Of Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Programmed Cell Death Regulation Of Cell Cycle Regulation Of Epidermis Development Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Signal Transduction Regulation Of Viral Transcription Organ Morphogenesis RNA Metabolic Process Neuron Fate Commitment Regulation Of Cellular Localization Anatomical Structure Formation Involved In Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Protein Phosphorylation Regulation Of Intracellular Transport	Regulation Of Viral Transcription Regulation Of Centriole Replication Trophoblast Giant Cell Differentiation G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Regulation Of Viral Process Regulation Of Microtubule-based Process Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Centrosome Duplication Cell Cycle Process Positive Regulation Of Viral Transcription Regulation Of Centrosome Cycle Centrosome Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Process Microtubule-based Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Positive Regulation Of Centriole Replication Transcription, RNA-templated Positive Regulation Of Histone H3-K9 Acetylation Cell Cycle DNA-templated Transcription, Elongation Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Centrosome Organization Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Cellular Response To Stress Microtubule Organizing Center Organization Embryonic Placenta Development Microtubule Cytoskeleton Organization Cellular Response To Indole-3-methanol Regulation Of Transcription, DNA-templated Maintenance Of Protein Location In Cell Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Maintenance Of Protein Location Negative Regulation Of Centriole Replication Positive Regulation Of Centrosome Duplication Maintenance Of Location In Cell Cell Differentiation Regulation Of Cytoskeleton Organization Response To Stress Regulation Of RNA Metabolic Process In Utero Embryonic Development
Tagcloud ?		aspirates biologically biomarker characterize correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Difference) ?		aspirates biologically biomarker characterize correlates deregulation display displaying grownin hematological hypermethylated hypermethylation malignancies methylation negatively neoplasms o2 occurrence oncogenesis perturbations plk1 plks polo promoter respond serve tension tumorigenesis	anomalies cleft clefts cnv cnvs comprise disrupting doi etiology fgf8 foxe1 gli2 grouped highlighting irf6 jhg journal kif7 lip mentioned msx1 msx2 ofc ofcs orofacial palate postulated satb2 ski
Tagcloud (Intersection) ?