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PLK4 and SFN
Number of citations of the paper that reports this interaction (PubMedID
16189514
)
0
Data Source:
BioGRID
(two hybrid, affinity chromatography technology)
HPRD
(two hybrid)
PLK4
SFN
Description
polo like kinase 4
stratifin
Image
GO Annotations
Cellular Component
XY Body
Nucleus
Nucleolus
Cytoplasm
Centrosome
Centriole
Cytosol
Cytoskeleton
Cleavage Furrow
Deuterosome
Procentriole
Procentriole Replication Complex
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Identical Protein Binding
Protein Serine Kinase Activity
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Cadherin Binding
Phosphoserine Residue Binding
Phosphoprotein Binding
Protein Sequestering Activity
Biological Process
Protein Phosphorylation
Centriole Replication
Regulation Of Cell Cycle Process
Positive Regulation Of Centriole Replication
Cilium Assembly
Trophoblast Giant Cell Differentiation
De Novo Centriole Assembly Involved In Multi-ciliated Epithelial Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Release Of Cytochrome C From Mitochondria
Keratinocyte Development
Negative Regulation Of Protein Kinase Activity
Protein Export From Nucleus
Signal Transduction
Intracellular Protein Localization
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Epidermal Cell Division
Negative Regulation Of Keratinocyte Proliferation
Regulation Of Cell-cell Adhesion
Keratinocyte Differentiation
Positive Regulation Of Cell Growth
Keratinization
Regulation Of Protein Localization
Defense Response To Bacterium
Skin Development
Keratinocyte Proliferation
Positive Regulation Of Epidermal Cell Differentiation
Positive Regulation Of Cell Adhesion
Negative Regulation Of Innate Immune Response
Positive Regulation Of Protein Export From Nucleus
Cytolysis In Another Organism
Regulation Of Cell Cycle
Establishment Of Skin Barrier
Stem Cell Proliferation
CAMP/PKA Signal Transduction
Non-canonical Inflammasome Complex Assembly
Negative Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Protein Localization
Negative Regulation Of Stem Cell Proliferation
Pathways
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
AURKA Activation by TPX2
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Regulation of localization of FOXO transcription factors
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs
Fostamatinib
Diseases
GWAS
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
27863252
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Eosinophil percentage of white cells (
32888494
)
Neutrophil percentage of granulocytes (
27863252
)
Interacting Genes
25 interacting genes:
ACTR2
AIRIM
ARR3
BTRC
CHD3
CYLD
DCAF1
DNAJB13
DRC4
ELOA
MIR126
MTUS2
OSBPL3
PRDM16
SFN
SMAD4
SPAG5
TAX1BP3
TEC
TENT5B
TENT5C
TFIP11
TGFBR1
TRIM54
ZBTB39
62 interacting genes:
ABL1
ARAF
BAD
BAX
BCR
BRAF
CCAR1
CCDC102B
CCDC125
CCNH
CDC25B
CDK1
CHST1
COP1
DUXAP9
EEF1A1
EGFR
EIF2S1
EIF4B
ENTREP1
EXO1
FAM53C
FAM9B
FOXO1
FOXO4
GPRIN2
HDAC5
HNRNPD
ING1
KCNK15
KCNK3
KCNK9
KIAA0408
LNX2
LONRF1
MAGEA1
MAP1A
MAP3K5
MARK3
MDM4
MKRN3
MST1R
NFIA
NFIB
NFIC
NR3C1
NTAQ1
PAX9
PLEKHF2
PLK4
RAB3IP
RAF1
RFFL
RNF126
SAMSN1
TBL3
TP53
TRIM25
TSC2
YWHAG
ZC2HC1C
ZFP36
Entrez ID
10733
2810
HPRD ID
10387
03185
Ensembl ID
ENSG00000142731
ENSG00000175793
Uniprot IDs
O00444
P31947
PDB IDs
2N19
3COK
4JXF
4N7V
4N7Z
4N9J
4YUR
4YYP
5LHY
5LHZ
6N45
6N46
6W38
6W3I
6W3J
8XPG
1YWT
1YZ5
3IQJ
3IQU
3IQV
3LW1
3MHR
3O8I
3P1N
3P1O
3P1P
3P1Q
3P1R
3P1S
3SMK
3SML
3SMM
3SMN
3SMO
3SP5
3SPR
3T0L
3T0M
3U9X
3UX0
4DAT
4DAU
4DHM
4DHN
4DHO
4DHP
4DHQ
4DHR
4DHS
4DHT
4DHU
4FL5
4FR3
4IEA
4JC3
4JDD
4QLI
4Y32
4Y3B
4Y5I
5BTV
5HF3
5LTW
5LU1
5LU2
5MHC
5MOC
5MXO
5MY9
5MYC
5N5R
5N5T
5N5W
5N75
5OEG
5OEH
5OK9
5OKF
5OM0
5OMA
6FAU
6FAV
6FAW
6FBB
6FBW
6FBY
6FCP
6FI4
6FI5
6G6X
6G8I
6G8J
6G8K
6G8L
6G8P
6G8Q
6GHP
6HHP
6HKB
6HKF
6HMT
6HMU
6HN2
6NV2
6QDR
6QDS
6QDT
6QDU
6QHL
6QHM
6QIU
6QZR
6QZS
6R5L
6RHC
6RJL
6RJQ
6RJZ
6RK8
6RKI
6RKK
6RKM
6RL3
6RL4
6RL6
6RM5
6RM7
6RP6
6RWH
6RWI
6RWS
6RWU
6RX2
6S39
6S3C
6S40
6S9Q
6SIN
6SIO
6SIP
6SIQ
6SLV
6SLW
6SLX
6T5F
6T5H
6T80
6TCH
6TJM
6TL3
6TLF
6TLG
6TM7
6TWZ
6W0L
6XWD
6XXC
6XY5
6Y18
6Y1D
6Y1J
6Y3M
6Y3O
6Y3R
6Y3S
6Y3V
6Y3W
6Y40
6Y44
6Y58
6Y7T
6Y8A
6Y8B
6Y8D
6Y8E
6YE9
6YIA
6YIB
6YIC
6YLU
6YOW
6YOX
6YOY
6YP2
6YP3
6YP8
6YPL
6YPY
6YQ2
6YR5
6YR6
6YR7
6ZCJ
6ZVB
6ZVC
6ZVD
6ZVE
7AEW
7AOG
7AXN
7AYF
7AZ1
7AZ2
7B13
7B15
7B9M
7B9R
7B9T
7BA3
7BA5
7BA6
7BA7
7BA8
7BA9
7BAA
7BAB
7BDP
7BDT
7BDY
7BFW
7BG3
7BGQ
7BGR
7BGV
7BGW
7BI3
7BIQ
7BIW
7BIY
7BJB
7BJF
7BJL
7BJW
7BKH
7BM9
7BMC
7NFW
7NIF
7NIG
7NIX
7NIZ
7NJ6
7NJ8
7NJ9
7NJA
7NJB
7NK3
7NK5
7NLA
7NLE
7NM1
7NM3
7NM9
7NMA
7NMH
7NMW
7NMX
7NN2
7NND
7NNE
7NP2
7NPB
7NPG
7NQP
7NR7
7NRK
7NRL
7NSV
7NV4
7NVI
7NWS
7NXS
7NXT
7NXW
7NXY
7NY4
7NYE
7NYF
7NYG
7NZ6
7NZG
7NZK
7NZV
7O07
7O34
7O3A
7O3F
7O3P
7O3Q
7O3R
7O3S
7O57
7O59
7O5A
7O5C
7O5D
7O5F
7O5G
7O5O
7O5P
7O5S
7O5U
7O5X
7O6F
7O6G
7O6I
7O6J
7O6K
7O6M
7O6O
7OB5
7OB8
7OBC
7OBD
7OBG
7OBH
7OBK
7OBL
7OBS
7OBT
7OBX
7OBY
7OPW
7OQ7
7OQ8
7OQ9
7OQA
7OQG
7OQJ
7OQS
7OQU
7OQW
7OR3
7OR5
7OR7
7OR8
7ORG
7ORH
7ORS
7ORT
7PWT
7PWZ
7QIK
7QIP
7ZMU
7ZMW
8A62
8A65
8A68
8A6F
8A6H
8ADM
8AFN
8AI0
8ALR
8ALT
8ALV
8ALW
8AM7
8ANB
8ANC
8ANF
8AOY
8APS
8AQ1
8AQC
8AQE
8AQZ
8AR4
8AR5
8ARG
8ARO
8ARQ
8ARR
8ARW
8ARX
8ARY
8ARZ
8AS1
8AT9
8ATP
8ATR
8ATS
8AU2
8AUS
8AUY
8AV0
8AV3
8AV4
8AV7
8AV8
8AWG
8AXE
8AXU
8AZE
8B2I
8B2K
8B39
8B4Q
8B5P
8BFC
8BI7
8BJG
8BJN
8BM5
8BTQ
8BWE
8BWH
8BWJ
8BWX
8BWZ
8BX0
8BX3
8BX4
8BXI
8BXM
8BXN
8BXO
8BXQ
8BXS
8BY9
8BYB
8BYC
8BYD
8BYE
8BYF
8BYG
8BYO
8BYY
8BYZ
8BZ0
8BZ9
8BZA
8BZB
8BZC
8BZD
8BZE
8BZF
8BZG
8BZH
8BZT
8BZW
8C04
8C0K
8C0L
8C1Y
8C28
8C2D
8C2E
8C2F
8C2G
8C2Y
8C30
8C3C
8C3Z
8C40
8C42
8C43
8C4F
8C4G
8P0D
8Q4L
8Q55
8Q5C
8R0Z
8RRK
8RRL
8RRM
8S42
9AXA
9F35
Enriched GO Terms of Interacting Partners
?
Cytoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Centrosome
Cytoskeleton
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Microtubule
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Extracellular Matrix Assembly
Endothelial Cell Activation
Poly(A) RNA Polymerase Activity
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
I-SMAD Binding
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Positive Regulation Of T Cell Receptor Signaling Pathway
Microtubule Binding
Regulation Of Extracellular Matrix Assembly
Positive Regulation Of Antigen Receptor-mediated Signaling Pathway
Positive Regulation Of Extracellular Matrix Organization
Microtubule-based Process
Regulation Of Cytoskeleton Organization
Activin Receptor Signaling Pathway
Cardiac Epithelial To Mesenchymal Transition
Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Centriolar Satellite
Regulation Of Primary Metabolic Process
Ciliary Basal Body
Phosphoprotein Binding
Negative Regulation Of Interleukin-18-mediated Signaling Pathway
Regulation Of Wnt Signaling Pathway
Met1-linked Polyubiquitin Deubiquitinase Activity
Negative Regulation Of Epithelial Cell Proliferation
Negative Regulation Of Cardiac Myofibril Assembly
Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis
Female Gonad Morphogenesis
Histone H2AT120 Kinase Activity
Cell Competition In A Multicellular Organism
Neuron Fate Commitment
Ventricular Septum Morphogenesis
Nucleus
Regulation Of Microtubule Cytoskeleton Organization
Positive Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Wnt Signaling Pathway
MAP Kinase Kinase Kinase Activity
Regulation Of Protein Metabolic Process
Protein Modification Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Primary Metabolic Process
Regulation Of Cell Population Proliferation
Positive Regulation Of Peptidyl-serine Phosphorylation
MAPK Cascade
Kinase Activity
Intracellular Signal Transduction
Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of Metabolic Process
Regulation Of Apoptotic Process
Response To Wounding
Protein Metabolic Process
Cellular Response To Oxidative Stress
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Regulation Of Action Potential Firing Rate
Apoptotic Process
DNA Strand Resection Involved In Replication Fork Processing
Response To Starvation
Potassium Ion Leak Channel Activity
Regulation Of Macromolecule Metabolic Process
Programmed Cell Death
Cell Death
Cellular Response To Reactive Nitrogen Species
Nucleus
Protein Serine Kinase Activity
Cellular Response To Acidic PH
Positive Regulation Of RNA Metabolic Process
Negative Regulation Of Protein Metabolic Process
Response To Oxidative Stress
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Apoptotic Process
Cellular Response To Chemical Stress
Regulation Of Metabolic Process
Regulation Of Intracellular Signal Transduction
Cellular Response To Starvation
Positive Regulation Of RNA Biosynthetic Process
Cellular Response To Oxygen-containing Compound
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Positive Regulation Of DNA-templated Transcription
Response To Nutrient Levels
Regulation Of Cell Cycle G2/M Phase Transition
Negative Regulation Of Programmed Cell Death
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Tagcloud (Intersection)
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