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RGS14 and RAP1A
Number of citations of the paper that reports this interaction (PMID
10926822
)
16
Data Source:
HPRD
(in vitro, two hybrid)
RGS14
RAP1A
Gene Name
regulator of G-protein signaling 14
RAP1A, member of RAS oncogene family
Image
Gene Ontology Annotations
Cellular Component
Spindle Pole
Nucleus
Cytoplasm
Centrosome
Spindle
Microtubule
Plasma Membrane
Postsynaptic Density
Nuclear Body
PML Body
Cell Junction
Dendrite
Dendritic Spine
Postsynaptic Membrane
Cytoplasm
Early Endosome
Late Endosome
Cytosol
Plasma Membrane
Cell Junction
Guanyl-nucleotide Exchange Factor Complex
Neuron Projection
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
G-protein Alpha-subunit Binding
Receptor Signaling Protein Activity
GDP-dissociation Inhibitor Activity
GTPase Activator Activity
Microtubule Binding
Protein Kinase Binding
Receptor Signaling Complex Scaffold Activity
GTPase Activating Protein Binding
GTPase Activity
Protein Binding
GTP Binding
Protein Transporter Activity
Ras GTPase Binding
Rap Guanyl-nucleotide Exchange Factor Activity
Protein Complex Binding
Biological Process
Nucleocytoplasmic Transport
Response To Oxidative Stress
Spindle Organization
Chromosome Segregation
Mitotic Nuclear Division
Learning
Long-term Memory
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Visual Learning
Zygote Asymmetric Cell Division
Negative Regulation Of Synaptic Plasticity
Intracellular Signal Transduction
Termination Of G-protein Coupled Receptor Signaling Pathway
Negative Regulation Of MAP Kinase Activity
Positive Regulation Of GTPase Activity
Regulation Of DNA-templated Transcription In Response To Stress
Platelet-derived Growth Factor Receptor Signaling Pathway
Positive Regulation Of Neurogenesis
Cell Division
Long-term Synaptic Potentiation
Negative Regulation Of ERK1 And ERK2 Cascade
Activation Of MAPKK Activity
Energy Reserve Metabolic Process
Signal Transduction
Blood Coagulation
Positive Regulation Of Neuron Projection Development
Protein Transport
Microvillus Assembly
Platelet Activation
Rap Protein Signal Transduction
Positive Regulation Of Rap GTPase Activity
Nerve Growth Factor Signaling Pathway
Small Molecule Metabolic Process
Positive Regulation Of Protein Kinase Activity
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Insulin Secretion
Establishment Of Endothelial Barrier
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To CAMP
Regulation Of Cell Junction Assembly
Cellular Response To Nerve Growth Factor Stimulus
Negative Regulation Of Synaptic Vesicle Exocytosis
Positive Regulation Of Vasculogenesis
Pathways
Signaling by GPCR
GPCR downstream signaling
G alpha (i) signalling events
Signalling to ERKs
Signalling by NGF
Prolonged ERK activation events
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Integration of energy metabolism
Regulation of insulin secretion
p130Cas linkage to MAPK signaling for integrins
Integrin alphaIIb beta3 signaling
NGF signalling via TRKA from the plasma membrane
GRB2:SOS provides linkage to MAPK signaling for Integrins
Platelet Aggregation (Plug Formation)
ARMS-mediated activation
Rap1 signalling
Platelet activation, signaling and aggregation
Frs2-mediated activation
Adaptive Immune System
Drugs
Diseases
GWAS
Activated partial thromboplastin time (
22703881
)
Chronic kidney disease (
20383146
)
Multiple sclerosis (
21833088
)
Nephrolithiasis (
22396660
)
Renal function-related traits (eGRFcrea) (
22797727
)
Renal function-related traits (sCR) (
22797727
)
Osteoporosis (
20548944
)
Protein-Protein Interactions
15 interactors:
APP
GNA11
GNAI1
GNAI2
GNAI3
GNAO1
NFKB1
POT1
PRKACA
RAP1A
RAP2A
TINF2
TRAF2
WAS
XPO1
41 interactors:
APBB1IP
ARHGEF1
BIN1
BMX
BRAF
FADD
FAF1
FAS
GABARAPL2
GANAB
HDAC1
HSPA1A
KRIT1
MLLT4
MTNR1A
NTRK1
PDE6D
PPP2R1A
PRKACA
RABAC1
RAF1
RALA
RALGDS
RAP1GAP
RAP1GDS1
RAPGEF2
RAPGEF3
RAPGEF4
RAPGEF5
RAPGEF6
RASA1
RASA3
RASGRP2
RASGRP4
RASIP1
RGL4
RGS14
RUNDC3A
SMARCA4
TCEB3
TNFRSF10C
Entrez ID
10636
5906
HPRD ID
03944
01545
Ensembl ID
ENSG00000169220
ENSG00000116473
Uniprot IDs
B3KUX0
O43566
A8KAH9
P62834
PDB IDs
2JNU
2OM2
2XNS
3ONW
3QI2
1C1Y
1GUA
3KUC
Enriched GO Terms of Interacting Partners
?
Platelet Activation
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Cell Activation
Response To Wounding
Cell Surface Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Regulation Of Catalytic Activity
Signal Transduction
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Response To Stress
Signaling
Cell Communication
Negative Regulation Of CAMP Biosynthetic Process
Negative Regulation Of CAMP Metabolic Process
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleotide Metabolic Process
Cellular Response To Stimulus
Negative Regulation Of Catalytic Activity
Negative Regulation Of Telomere Maintenance Via Telomerase
Positive Regulation Of Cellular Metabolic Process
Positive Regulation Of Metabolic Process
Regulation Of Adenylate Cyclase Activity
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Telomere Assembly
Negative Regulation Of Glial Cell Apoptotic Process
Negative Regulation Of Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cyclase Activity
Negative Regulation Of Cellular Metabolic Process
Rap Protein Signal Transduction
Negative Regulation Of Telomere Maintenance
Regulation Of Phosphorus Metabolic Process
Regulation Of Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Telomere Maintenance
Regulation Of Telomere Maintenance Via Telomerase
Activation Of Protein Kinase Activity
Regulation Of CAMP Biosynthetic Process
Positive Regulation Of Hydrolase Activity
Regulation Of Protein Phosphorylation
Regulation Of MAPK Cascade
Regulation Of CAMP Metabolic Process
Regulation Of Cellular Process
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Catalytic Activity
Positive Regulation Of Catalytic Activity
Positive Regulation Of Hydrolase Activity
Regulation Of GTPase Activity
Positive Regulation Of GTPase Activity
Positive Regulation Of Metabolic Process
Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Rap GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Small GTPase Mediated Signal Transduction
Regulation Of Signaling
Regulation Of Ras Protein Signal Transduction
Regulation Of Ras GTPase Activity
Regulation Of Rap GTPase Activity
Positive Regulation Of Ras GTPase Activity
Intracellular Signal Transduction
Regulation Of Rap Protein Signal Transduction
Signal Transduction
Cell Communication
Regulation Of Metabolic Process
Cellular Response To Stimulus
Signaling
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Response To Stimulus
Ras Protein Signal Transduction
Enzyme Linked Receptor Protein Signaling Pathway
Neurotrophin Signaling Pathway
Regulation Of Cellular Process
Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Cellular Component Organization
Positive Regulation Of Cyclic Nucleotide Metabolic Process
Cellular Response To Growth Factor Stimulus
Response To Growth Factor
Regulation Of Apoptotic Process
Regulation Of Cell Death
Cell Activation
Regulation Of Protein Kinase Activity
Negative Regulation Of Signaling
Regulation Of Kinase Activity
Cell Surface Receptor Signaling Pathway
Platelet Activation
Regulation Of Cell Differentiation
Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Signal Transduction
Positive Regulation Of Lyase Activity
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Programmed Cell Death
Cell Differentiation
Tagcloud
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Difference)
?
bfa
bisphosphonates
brefeldin
camp
cathepsin
cdc42
cytoskeletal
diminish
diminished
epac
epac1
epac2
esi
fak
intermediates
isoprenylation
ko
multinucleated
nfatc1
nfkb
osteoclast
osteopontin
pctp
permit
rac1
rankl
raw264
rhoa
Tagcloud (Intersection)
?