RGS14 and RAP2A

Number of citations of the paper that reports this interaction (PMID 10926822)
16

Data Source:
HPRD (in vitro, two hybrid)

		RGS14	RAP2A
Gene Name		regulator of G-protein signaling 14	RAP2A, member of RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Cell Junction Dendrite Dendritic Spine Postsynaptic Membrane	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	G-protein Alpha-subunit Binding Receptor Signaling Protein Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Microtubule Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity GTPase Activating Protein Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Mitotic Nuclear Division Learning Long-term Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events
Drugs			Guanosine-5\'-Triphosphate Guanosine-5\'-Diphosphate
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Multiple sclerosis ( 21833088) Nephrolithiasis ( 22396660) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)
Protein-Protein Interactions		15 interactors: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 WAS XPO1	32 interactors: ACVR1 ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 MLLT4 NEDD4 PLG RAF1 RALA RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		10636	5911
HPRD ID		03944	01547
Ensembl ID		ENSG00000169220
Uniprot IDs		B3KUX0 O43566	P10114
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Catalytic Activity Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stress Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Telomere Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Cellular Metabolic Process Rap Protein Signal Transduction Negative Regulation Of Telomere Maintenance Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Activation Of Protein Kinase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process	Intracellular Signal Transduction Response To Stimulus Regulation Of Signaling Regulation Of Catalytic Activity Cell Communication Signal Transduction Cellular Response To Stimulus Positive Regulation Of Metabolic Process Positive Regulation Of Rap GTPase Activity Signaling Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rap GTPase Activity Positive Regulation Of Catalytic Activity Regulation Of Rap Protein Signal Transduction Signal Transduction By Phosphorylation Regulation Of Metabolic Process Small GTPase Mediated Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Regulation Of GTPase Activity Wound Healing Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Ras Protein Signal Transduction Regulation Of Dendrite Morphogenesis Response To Wounding Regulation Of Cell Projection Organization Positive Regulation Of GTPase Activity Positive Regulation Of Hydrolase Activity Platelet Activation Regulation Of Ras GTPase Activity Cellular Response To Growth Factor Stimulus Response To Organic Substance Regulation Of Cellular Process Response To Growth Factor Regulation Of Dendrite Development Cardiovascular System Development Cell Surface Receptor Signaling Pathway Positive Regulation Of Ras GTPase Activity Regulation Of Cell Differentiation Negative Regulation Of Cell Proliferation Cell Activation Regulation Of Cellular Localization Cell Differentiation Blood Vessel Development Response To Stress Vasculature Development Regulation Of Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Activation Of MAPKK Activity
Tagcloud ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Difference) ?			cleave competitors degrades diaminopimelic effectors endopeptidase endopeptidases exploiting extrude heteromeric marcescens meso muropeptides neutralization neutralize orthologues pentapeptides promiscuity rap1a raps serratia ssp1 ssp2 steric tetrapenta tetrapeptides tetratetra tetratetrapeptides tripeptides
Tagcloud (Intersection) ?