RGS14 and GNAO1

Number of citations of the paper that reports this interaction (PMID 10926822)
16

Data Source:
HPRD (in vitro)

		RGS14	GNAO1
Gene Name		regulator of G-protein signaling 14	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Cell Junction Dendrite Dendritic Spine Postsynaptic Membrane	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	G-protein Alpha-subunit Binding Receptor Signaling Protein Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Microtubule Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity GTPase Activating Protein Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Mitotic Nuclear Division Learning Long-term Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Multiple sclerosis ( 21833088) Nephrolithiasis ( 22396660) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)
Protein-Protein Interactions		15 interactors: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 WAS XPO1	34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		10636	2775
HPRD ID		03944	00757
Ensembl ID		ENSG00000169220	ENSG00000087258
Uniprot IDs		B3KUX0 O43566	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Catalytic Activity Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stress Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Telomere Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Cellular Metabolic Process Rap Protein Signal Transduction Negative Regulation Of Telomere Maintenance Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Activation Of Protein Kinase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell
Tagcloud ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?			aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?