RGS14 and XPO1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RGS14	XPO1
Gene Name		regulator of G-protein signaling 14	exportin 1
Image
Gene Ontology Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Microtubule Plasma Membrane Postsynaptic Density Nuclear Body PML Body Cell Junction Dendrite Dendritic Spine Postsynaptic Membrane	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Ribonucleoprotein Complex Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	G-protein Alpha-subunit Binding Receptor Signaling Protein Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Microtubule Binding Protein Kinase Binding Receptor Signaling Complex Scaffold Activity GTPase Activating Protein Binding	RNA Binding Transporter Activity Nucleocytoplasmic Transporter Activity Protein Binding Ran GTPase Binding Protein Transporter Activity Protein Domain Specific Binding
	Biological Process	Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Mitotic Nuclear Division Learning Long-term Memory Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Visual Learning Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Intracellular Signal Transduction Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Positive Regulation Of GTPase Activity Regulation Of DNA-templated Transcription In Response To Stress Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Protein Export From Nucleus Transforming Growth Factor Beta Receptor Signaling Pathway Gene Expression Regulation Of Centrosome Duplication Viral Process Viral Life Cycle Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Catabolic Process Response To Drug Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus
Pathways		Signaling by GPCR GPCR downstream signaling G alpha (i) signalling events	Loss of Function of TGFBR2 in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Signaling by Wnt TGF-beta receptor signaling activates SMADs Influenza Life Cycle Export of Viral Ribonucleoproteins from Nucleus RNF mutants show enhanced WNT signaling and proliferation Regulation of mRNA stability by proteins that bind AU-rich elements TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Host Interactions of HIV factors Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer Influenza Infection Late Phase of HIV Life Cycle Resolution of Sister Chromatid Cohesion Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Mitotic Prometaphase Separation of Sister Chromatids HIV Infection Rev-mediated nuclear export of HIV RNA G2/M Transition Mitotic Anaphase TGFBR1 LBD Mutants in Cancer HuR stabilizes mRNA deactivation of the beta-catenin transactivating complex M Phase HIV Life Cycle Rev-mediated nuclear export of HIV RNA Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN NEP/NS2 Interacts with the Cellular Export Machinery Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Interactions of Rev with host cellular proteins Cell Cycle, Mitotic Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer TCF dependent signaling in response to WNT Signaling by WNT in cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Multiple sclerosis ( 21833088) Nephrolithiasis ( 22396660) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727)
Protein-Protein Interactions		15 interactors: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 WAS XPO1	72 interactors: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA PXN RAN RANBP1 RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SNUPN SOX2 STAT1 STRADA TERF2IP TERT TOP2A TOP2B TP73
Entrez ID		10636	7514
HPRD ID		03944	03975
Ensembl ID		ENSG00000169220	ENSG00000082898
Uniprot IDs		B3KUX0 O43566	B3KWD0 O14980
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2	1W9C 2L1L 3GB8 4BSM 4BSN
Enriched GO Terms of Interacting Partners?		Platelet Activation Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Cell Activation Response To Wounding Cell Surface Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Catalytic Activity Signal Transduction Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stress Signaling Cell Communication Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Nucleotide Metabolic Process Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Telomere Assembly Negative Regulation Of Glial Cell Apoptotic Process Negative Regulation Of Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Cyclase Activity Negative Regulation Of Cellular Metabolic Process Rap Protein Signal Transduction Negative Regulation Of Telomere Maintenance Regulation Of Phosphorus Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Activation Of Protein Kinase Activity Regulation Of CAMP Biosynthetic Process Positive Regulation Of Hydrolase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Regulation Of CAMP Metabolic Process Regulation Of Cellular Process Positive Regulation Of Cellular Protein Metabolic Process	Cell Cycle Cell Cycle Process Nucleocytoplasmic Transport Mitotic Cell Cycle Nuclear Transport Mitotic Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Regulation Of Mitotic Cell Cycle Regulation Of Metabolic Process Organelle Organization Cytoplasmic Transport Nuclear Export Positive Regulation Of Gene Expression Cellular Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Gene Expression Negative Regulation Of Kinase Activity Negative Regulation Of Cellular Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Protein Export From Nucleus Intracellular Transport Response To Organic Substance Negative Regulation Of Phosphorylation RNA Transport RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Localization Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Protein Kinase Activity Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity RNA Metabolic Process Negative Regulation Of Protein Phosphorylation Regulation Of Cellular Process Regulation Of Kinase Activity Regulation Of Cell Cycle Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cell Proliferation Regulation Of Cellular Protein Metabolic Process Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity
Tagcloud ?			accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Difference) ?			accounting atm bioinformatics birc3 concordance confirmation conservative cutoff discordant eventually haloplex hiseq ighv ighv3 klhl6 lymphocytic myd88 next notch1 pot1 precision recurrently repeating reproducible sanger sequencing sf3b1 stand unmutated
Tagcloud (Intersection) ?