RGS14 and TINF2

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		RGS14	TINF2
Description		regulator of G protein signaling 14	TERF1 interacting nuclear factor 2
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GO Annotations	Cellular Component	Spindle Pole Nucleus Cytoplasm Centrosome Spindle Cytoskeleton Microtubule Plasma Membrane Postsynaptic Density Membrane Nuclear Body PML Body Dendrite Cell Projection Dendritic Spine Synapse Glutamatergic Synapse	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Perinucleolar Chromocenter Nuclear Matrix Nuclear Body Shelterin Complex
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Microtubule Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity GTPase Regulator Activity GTPase Activating Protein Binding	DNA Binding Protein Binding Telomeric DNA Binding
	Biological Process	Mitotic Cell Cycle Nucleocytoplasmic Transport Response To Oxidative Stress Spindle Organization Chromosome Segregation Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Long-term Memory Regulation Of G Protein-coupled Receptor Signaling Pathway Visual Learning Negative Regulation Of Signal Transduction Zygote Asymmetric Cell Division Negative Regulation Of Synaptic Plasticity Negative Regulation Of MAP Kinase Activity Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Cell Division Long-term Synaptic Potentiation Negative Regulation Of ERK1 And ERK2 Cascade	Telomere Capping Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Epithelial Cell Proliferation Protein Localization To Chromosome, Telomeric Region Regulation Of Telomere Maintenance Via Telomere Lengthening
Pathways		G alpha (i) signalling events G alpha (i) signalling events	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases			Revesz syndrome; Exudative retinopathy with bone marrow failure
GWAS		Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Blood urea nitrogen levels ( 31152163) Calcium levels ( 24068962) Chronic kidney disease ( 20383146 31152163) Circulating fibroblast growth factor 23 levels ( 30217807) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 21833088 24076602) Nephrolithiasis ( 22396660) Phosphorus levels ( 29403010) Red blood cell count ( 27863252 32888494) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum parathyroid hormone levels ( 27927781) Ulcerative colitis ( 28067908) Urolithiasis ( 30975718) Vitamin C levels ( 33203707) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Leukocyte telomere length ( 31171785) Platelet count ( 29403010)
Interacting Genes		16 interacting genes: APP GNA11 GNAI1 GNAI2 GNAI3 GNAO1 NFKB1 POT1 PRKACA RAP1A RAP2A TINF2 TRAF2 VIPR2 WAS XPO1	91 interacting genes: ACD ACOT7 ACTB ADA AFAP1L2 AIPL1 AK1 ANKMY2 ANXA4 ANXA5 ANXA8L1 APOBEC3F APPL2 ARHGDIA ARID3B BAG3 BIN2 CALD1 CCDC43 CCDC9 CKB CLK3 CPNE3 CRYGS CSNK2A1 CTTN DBN1 DCX DHFR2 DPP3 EEF1D EIF4B ENO2 FAM131B FERMT3 FKBP6 GAPDH GNMT HNMT HOXA3 HSP90AB1 IPO5 KCTD17 LASP1 LDHA LGALSL LTA4H MAP2K3 MTNR1B NCDN NOL3 NUDC NUDCD2 OR2H1 PAGE2 PAK1IP1 PEX5 PFKP PGM1 PGM2 PHPT1 PKM PPP1R2 PPP6R3 PRKCB REM2 RGS14 RPSA SARS1 SCRN2 SIAH2 STUB1 SULT1C2 TAGLN TBL1X TERF1 TERF2 TFRC TOMM34 TPP1 TRIM15 TRIM16 TRIP10 TUBB TUBB4B TXNDC17 UCHL1 VIPR1 YWHAG ZFP36L1 ZNF790
Entrez ID		10636	26277
HPRD ID		03944	16056
Ensembl ID		ENSG00000169220	ENSG00000092330
Uniprot IDs		O43566	B4DFJ1 Q9BSI4
PDB IDs		2JNU 2OM2 2XNS 3ONW 3QI2	3BQO 3BU8 5XYF
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein Activity G Protein-coupled Receptor Binding GTPase Activity G Protein-coupled Receptor Signaling Pathway GTP Binding Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway GDP Binding Signal Transduction G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Protein Transport G Protein-coupled Serotonin Receptor Binding Postsynaptic Modulation Of Chemical Synaptic Transmission Modulation Of Chemical Synaptic Transmission Regulation Of Biological Quality Adenylate Cyclase Regulator Activity Telomere Assembly Regulation Of Transport Regulation Of Establishment Of Protein Localization Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Regulation Of Secretion By Cell Negative Regulation Of Secretion By Cell Regulation Of Protein Localization Shelterin Complex Regulation Of Insulin Secretion Regulation Of Secretion Negative Regulation Of Secretion Regulation Of Cellular Component Organization Midbody Nuclear Telomere Cap Complex Synaptic Membrane Regulation Of Peptide Hormone Secretion Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Rap Protein Signal Transduction Telomere Capping Cell Body Regulation Of Steroid Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cellular Response To Forskolin Regulation Of Cell Junction Assembly Nucleotide Binding Regulation Of Hormone Secretion	Cytosol Extracellular Exosome Cytoplasm ADP Metabolic Process Purine Ribonucleotide Catabolic Process Ribonucleoside Diphosphate Metabolic Process Glycolytic Process ADP Catabolic Process Purine Nucleotide Catabolic Process Nucleoside Phosphate Catabolic Process Nucleoside Diphosphate Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Catabolic Process Nucleoside Diphosphate Catabolic Process Cadherin Binding Pyruvate Metabolic Process Nucleotide Catabolic Process Carbohydrate Catabolic Process Shelterin Complex Organophosphate Catabolic Process Glucose Metabolic Process RNA-templated DNA Biosynthetic Process Nuclear Telomere Cap Complex Glucose Catabolic Process Nucleobase-containing Compound Catabolic Process Protein Localization To Chromosome, Telomeric Region ATP Metabolic Process Hexose Metabolic Process Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Telomere Capping Nicotinamide Nucleotide Metabolic Process Purine-containing Compound Metabolic Process Generation Of Precursor Metabolites And Energy Ficolin-1-rich Granule Lumen Nucleobase-containing Small Molecule Metabolic Process Monosaccharide Metabolic Process Carbohydrate Derivative Catabolic Process Phosphoglucomutase Activity Nucleoside Metabolic Process Protein Binding Purine Ribonucleotide Metabolic Process Calcium-dependent Phospholipid Binding Cellular Response To Heat Canonical Glycolysis Negative Regulation Of Apoptotic Process Negative Regulation Of Telomere Maintenance Via Telomerase Ribonucleotide Metabolic Process Glycolytic Process Through Glucose-6-phosphate Glycolytic Process Through Fructose-6-phosphate
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