LAMTOR5 and GAPDH

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		LAMTOR5	GAPDH
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP	Nucleus Cytoplasm Lipid Droplet Cytosol Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The Aldehyde Or Oxo Group Of Donors, NAD Or NADP As Acceptor Transferase Activity Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling	Microtubule Cytoskeleton Organization Positive Regulation Of Cytokine Production Immune System Process Glucose Metabolic Process Glycolytic Process Regulation Of Translation Apoptotic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Another Organism Positive Regulation Of Type I Interferon Production Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Type II Interferon
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Glycolysis Gluconeogenesis
Drugs			NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper Artenimol
Diseases
GWAS			Blood protein levels ( 30072576)
Interacting Genes		63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	92 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CEBPA CHP1 DUX4 DYNLL1 EGFR ERBB2 FBXO7 FKBP6 FOXP1 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT ITGB5 KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 LINC01554 MAPK1 MTNR1A MYOC NFYC NR1H4 NUFIP2 OGT OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 RXFP4 S100A6 SERPINB9 SHANK3 SIAH1 SIRT1 SLC2A1 SLC2A4 SMARCA2 SMN1 SUMO4 TERF1 TINF2 TK1 TPPP TSC2 TXNIP USP25 WEE2-AS1 YWHAE YWHAQ
Entrez ID		10542	2597
HPRD ID		09773	00713
Ensembl ID		ENSG00000134248	ENSG00000111640
Uniprot IDs		A0A8Z5A536 O43504	P04406 V9HVZ4
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1U8F 1ZNQ 3GPD 4WNC 4WNI 6ADE 6IQ6 6M61 6YND 6YNE 6YNF 6YNH 8DNS 8G12 8G13 8G14 8G15 8G16 8G17 8P5F
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding	Developmental Process Cellular Developmental Process Nucleus Cell Differentiation Regulation Of Programmed Cell Death Regulation Of Phosphorus Metabolic Process Shelterin Complex Regulation Of Cellular Component Organization Negative Regulation Of Metabolic Process Intracellular Signal Transduction Positive Regulation Of DNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Nuclear Telomere Cap Complex Protein-containing Complex Regulation Of Cellular Localization Cellular Response To Stress Regulation Of Cellular Response To Stress Regulation Of Multicellular Organismal Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Protein Localization Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Capping Regulation Of Phosphorylation Nucleoplasm Regulation Of Developmental Process Negative Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process Telomere Assembly Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cell Cycle Regulation Of Chromosome Organization Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Population Proliferation Negative Regulation Of Biosynthetic Process Cytosol Positive Regulation Of Programmed Cell Death Positive Regulation Of Signaling Positive Regulation Of Chromosome Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Development Positive Regulation Of Cellular Component Organization System Development
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