LAMTOR5 and BHMT

Number of citations of the paper that reports this interaction (PubMedID 23241634)
0

Data Source:
BioGRID (two hybrid)

		LAMTOR5	BHMT
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	betaine--homocysteine S-methyltransferase
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Methyltransferase Activity S-methyltransferase Activity Zinc Ion Binding Transferase Activity Metal Ion Binding Betaine-homocysteine S-methyltransferase Activity
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling	Protein Methylation Modified Amino Acid Metabolic Process Amino-acid Betaine Metabolic Process Amino-acid Betaine Catabolic Process Methionine Biosynthetic Process Methylation S-adenosylmethionine Metabolic Process Regulation Of Homocysteine Metabolic Process 'de Novo' L-methionine Biosynthetic Process L-methionine Salvage
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Sulfur amino acid metabolism Choline catabolism
Drugs			Methionine S-(D-Carboxybutyl)-L-Homocysteine Betaine
Diseases
GWAS			Betaine levels in individuals undergoing cardiac evaluation ( 26822151) Blood and toenail selenium levels ( 25343990) Blood trace element (Se levels) ( 23720494) Metabolite levels ( 23378610 23823483) Serum metabolite levels ( 33031748) Toenail selenium levels ( 25343990)
Interacting Genes		63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	6 interacting genes: ALG9 BBS1 BBS2 BBS4 LAMTOR3 LAMTOR5
Entrez ID		10542	635
HPRD ID		09773	04200
Ensembl ID		ENSG00000134248	ENSG00000145692
Uniprot IDs		A0A8Z5A536 O43504	Q93088 V9HWA4
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1LT7 1LT8 4M3P 8D45
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding	BBSome Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Regulation Of Cilium Beat Frequency Striatum Development Brain Morphogenesis Regulation Of Cilium Movement Photoreceptor Cell Maintenance Non-motile Cilium Assembly Regulation Of Microtubule-based Movement Ciliary Membrane Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Ragulator Complex Hippocampus Development Cerebral Cortex Development FNIP-folliculin RagC/D GAP Leptin-mediated Signaling Pathway Negative Regulation Of Appetite Fat Cell Differentiation Centriolar Satellite Adult Behavior Regulation Of Response To Food Retina Homeostasis Response To Leptin Ventricular System Development Protein Localization To Organelle Visual Perception Sensory Perception Of Light Stimulus RNA Polymerase II-specific DNA-binding Transcription Factor Binding Establishment Of Melanosome Localization Melanosome Localization Melanosome Transport Pigment Granule Transport Regulation Of Appetite Pigment Granule Localization Motile Cilium Positive Regulation Of Multicellular Organism Growth Regulation Of Response To Nutrient Levels Intracellular Protein Localization Golgi To Plasma Membrane Protein Transport Regulation Of Microtubule-based Process Cilium Assembly Cilium Organization Dendrite Development Establishment Of Protein Localization To Plasma Membrane Plasma Membrane Bounded Cell Projection Assembly Cell Projection Assembly Protein Localization To Cilium Golgi To Plasma Membrane Transport TORC1 Signaling Positive Regulation Of TORC1 Signaling
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