LAMTOR5 and AKR1C2

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		LAMTOR5	AKR1C2
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	aldo-keto reductase family 1 member C2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP	Cytoplasm Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Aldose Reductase (NADPH) Activity Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Carboxylic Acid Binding Bile Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Ketosteroid Monooxygenase Activity Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Indanol Dehydrogenase Activity
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling	Alcohol Metabolic Process Lipid Metabolic Process Prostaglandin Metabolic Process G Protein-coupled Receptor Signaling Pathway Digestion Steroid Metabolic Process Positive Regulation Of Cell Population Proliferation Epithelial Cell Differentiation Monocarboxylic Acid Metabolic Process Hormone Metabolic Process Progesterone Metabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Jasmonic Acid Stimulus Cellular Response To Prostaglandin D Stimulus
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol
Drugs			NADH Ursodeoxycholic acid Nicotinamide adenine dinucleotide phosphate Chenodeoxycholic acid Epitestosterone
Diseases
GWAS			Height ( 28552196) Hip index ( 34021172) Longevity ( 26912274) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	1 interacting genes: LAMTOR5
Entrez ID		10542	1646
HPRD ID		09773	11857
Ensembl ID		ENSG00000134248	ENSG00000151632
Uniprot IDs		A0A8Z5A536 O43504	B4DK69 P52895
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	1IHI 1J96 1XJB 2HDJ 2IPJ 4JQ1 4JQ2 4JQ3 4JQ4 4JQA 4JTQ 4JTR 4L1W 4L1X 4XO6 4XO7
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding	FNIP-folliculin RagC/D GAP Ragulator Complex Protein Localization To Lysosome Regulation Of Interleukin-8 Production Positive Regulation Of TOR Signaling Protein Localization To Vacuole Positive Regulation Of TORC1 Signaling Regulation Of Cell Size Regulation Of TORC1 Signaling Viral Genome Replication TOR Signaling Positive Regulation Of Protein Localization To Nucleus Cellular Response To Amino Acid Stimulus TORC1 Signaling Positive Regulation Of Interleukin-8 Production Response To Amino Acid Regulation Of TOR Signaling Late Endosome Membrane Viral Process Regulation Of Protein Localization To Nucleus Molecular Adaptor Activity
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