LAMTOR5 and C9

Number of citations of the paper that reports this interaction (PubMedID 23241634)
0

Data Source:
BioGRID (two hybrid)

		LAMTOR5	C9
Description		late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	complement C9
Image
GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP	Extracellular Region Membrane Attack Complex Extracellular Space Plasma Membrane Membrane Other Organism Cell Membrane Extracellular Exosome Blood Microparticle Transmembrane Transporter Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling	Cell Killing Immune System Process Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Killing Of Cells Of Another Organism Innate Immune Response Positive Regulation Of Immune Response Protein Homooligomerization Complement Activation, GZMK Pathway
Pathways		Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1	Terminal pathway of complement Regulation of Complement cascade
Drugs			Copper
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS			Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) Health literacy ( 31250787) Systemic lupus erythematosus ( 19838195)
Interacting Genes		63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592	4 interacting genes: C8A CD59 CLU LAMTOR5
Entrez ID		10542	735
HPRD ID		09773	00408
Ensembl ID		ENSG00000134248	ENSG00000113600
Uniprot IDs		A0A8Z5A536 O43504	P02748
PDB IDs		3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB	5FMW 6DLW 6H03 6H04 7NYC 7NYD 8B0G 8B0H 8DE6
Enriched GO Terms of Interacting Partners?		Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding	Complement Activation Negative Regulation Of Activation Of Membrane Attack Complex Negative Regulation Of Complement-dependent Cytotoxicity Complement Binding Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Complement Activation Regulation Of Complement Activation Humoral Immune Response Complement Activation, Classical Pathway Protein Sequestering Activity Immune Effector Process Regulation Of Humoral Immune Response Activation Of Immune Response Protein Localization To Lysosome Protein Localization To Vacuole Positive Regulation Of Immune Response Perinuclear Endoplasmic Reticulum Lumen Regulation Of Neuronal Signal Transduction Blood Microparticle Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Immune Response Central Nervous System Myelin Maintenance Immune Complex Clearance Positive Regulation Of Immune System Process Negative Regulation Of Immune Response Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Chromaffin Granule Response To Other Organism Positive Regulation Of Inclusion Body Assembly Neurofibrillary Tangle Positive Regulation Of Amyloid Fibril Formation Ragulator Complex Immune Response Regulation Of Neurofibrillary Tangle Assembly Membrane Attack Complex Other Organism Cell Membrane Protein Import Response To External Biotic Stimulus Spherical High-density Lipoprotein Particle FNIP-folliculin RagC/D GAP Microglial Cell Proliferation Extracellular Space Protein Carrier Chaperone Protein-containing Complex Binding Complement Activation, GZMK Pathway Regulation Of Immune System Process Transmembrane Transporter Complex Response To Virus Response To Misfolded Protein Negative Regulation Of Amyloid Fibril Formation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?