DEAF1 and TK1

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		DEAF1	TK1
Gene Name		DEAF1 transcription factor	thymidine kinase 1, soluble
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytoplasm	Cytosol
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Thymidine Kinase Activity ATP Binding Zinc Ion Binding Nucleoside Kinase Activity Identical Protein Binding
	Biological Process	Behavioral Fear Response Neural Tube Closure Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Germ Cell Development Visual Learning Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Embryonic Skeletal System Development	Liver Development Nucleobase-containing Compound Metabolic Process Pyrimidine Nucleobase Metabolic Process Deoxyribonucleoside Monophosphate Biosynthetic Process Nucleotide Biosynthetic Process Response To Toxic Substance Skeletal Muscle Cell Proliferation Phosphorylation Response To Nutrient Levels Pyrimidine Nucleoside Salvage Small Molecule Metabolic Process Thymidine Metabolic Process Response To Copper Ion Digestive Tract Development Protein Homotetramerization Response To Cortisol Nucleobase-containing Small Molecule Metabolic Process Fetal Process Involved In Parturition DNA Biosynthetic Process
Pathways			Pyrimidine salvage reactions Pyrimidine metabolism Metabolism of nucleotides
Drugs			Dithioerythritol Thymidine-5\'-Triphosphate
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A FHL1 GSK3A GSK3B HRAS HRSP12 INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B TK1	159 interactors: A1BG A2M AAMP ABHD4 ACTB ACTL6B ACTR1B ADAMTS10 ADD1 AGAP1 ALAS1 ALB APLP1 APP ARFGAP1 ASNA1 ATG16L2 ATP5B ATP6V1A ATXN3 BAG6 C14orf1 C19orf60 CARHSP1 CCDC115 CCDC90B CDC20 CDK1 CDK4 CDKN1A CENPB CHGB CLEC3B COL11A2 COL4A2 COL4A5 COPS6 CPNE6 CPSF3L CRIP2 CRMP1 CSAD DACT1 DALRD3 DCAF13 DDAH2 DEAF1 DMPK DOCK7 DRAP1 DUS2 DYNC1I1 EEF1A1 EIF3G EIF4A2 EIF6 EXT2 EZH2 F13A1 FAF1 FAM20C FBN3 FGB FLAD1 FST FZR1 GAPDH GDF9 GDI1 GLB1 GPCPD1 HADHB HERC3 HMGXB3 HSPBAP1 IER3IP1 IGHM IMMT INPP5K ITSN1 JADE1 JMJD1C KDM6B KIF21B KIF5A KLHL23 KLHL5 KMT2B LOC148413 LRIF1 MAGEA4 MAST2 MED31 METTL23 MKI67 MPP1 MPPED1 MRFAP1 MRPL37 MSH2 NEUROD2 NGFR NKIRAS2 NMT2 NRBP1 ODC1 PAAF1 PDE4DIP PKM PLD3 PLXNA3 PPP4C PROC PSME1 PTPN4 PTPRK QARS RBBP4 RBM48 RPA1 RPL13 RPS2 RUVBL1 RXRA SDF4 SEMA5B SEPT6 SETDB1 SEZ6L2 SMC5 SNX1 SP110 SULT1A3 SUMO3 TAF1C TCTEX1D2 THOC3 TIAM2 TLE1 TMSB4X TP53 TRIM46 TRMT2A TSC2 TTC38 TUBA1A TUBB2A TUBB3 TYK2 UNC119 UPF2 USP4 WDR18 WDR60 WDR73 WIZ ZBTB16 ZNF431 ZXDC
Entrez ID		10522	7083
HPRD ID		04027	01771
Ensembl ID		ENSG00000177030	ENSG00000167900
Uniprot IDs		O75398	P04183
PDB IDs		2JW6 4A24	1W4R 1XBT 2ORV 2WVJ
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Glycogen Metabolic Process Positive Regulation Of Protein Modification Process Polysaccharide Metabolic Process Regulation Of Protein Phosphorylation Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Senescence Regulation Of Glycogen Biosynthetic Process Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Hypermethylation Of CpG Island Energy Reserve Metabolic Process Regulation Of Glycogen Metabolic Process Response To Growth Factor Regulation Of Cellular Component Organization Apoptotic Process Regulation Of Cell Growth Negative Regulation Of Cell Growth Cellular Response To Interleukin-3 Programmed Cell Death Regulation Of Phosphorus Metabolic Process Cellular Metabolic Process Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Death Death Tube Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Mitotic Cell Cycle Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Kinase Activity Response To Fibroblast Growth Factor Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Immune Response-regulating Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Fc-epsilon Receptor Signaling Pathway Regulation Of Generation Of Precursor Metabolites And Energy Cellular Carbohydrate Metabolic Process Negative Regulation Of Cardiac Muscle Hypertrophy	Cellular Metabolic Process Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Developmental Process Anatomical Structure Development System Development Regulation Of Cellular Protein Metabolic Process Cellular Nitrogen Compound Metabolic Process Multicellular Organismal Development Cellular Localization Metabolic Process Regulation Of Metabolic Process Organelle Organization Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Protein Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Catabolic Process RNA Metabolic Process Negative Regulation Of Cell Cycle Posttranscriptional Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Cellular Metabolic Process Cell Differentiation Platelet Degranulation Gene Expression Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Cellular Process Biosynthetic Process Regulation Of Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cycle Process Mitotic Cell Cycle Process Axon Guidance Chromatin Organization Viral Process Programmed Cell Death Negative Regulation Of Mitotic Cell Cycle Phase Transition Chromosome Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Organic Substance Mitotic Cell Cycle Cellular Response To Growth Factor Stimulus
Tagcloud ?		abundantly believed carcinomas cardiomyocyte dysfunction enhancer epigenetic gather growing interest list making methylate myeloid mynd myogenesis nervy putative regulator relevance remodeling skeletal smyd suppressor transduction trithorax variegation variety zeste	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Difference) ?		abundantly believed carcinomas cardiomyocyte dysfunction enhancer epigenetic gather growing interest list making methylate myeloid mynd myogenesis nervy putative regulator relevance remodeling skeletal smyd suppressor transduction trithorax variegation variety zeste	american artiodactyla assigned block blot cattle chr conservative conserved cow electrophoresis erbb2 hybrid hybridization localization localized means mink nf1 pepa pig prkca rara representatives sheep southern swine synteny umph2
Tagcloud (Intersection) ?