DEAF1 and AIMP2

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		DEAF1	AIMP2
Description		DEAF1 transcription factor	aminoacyl tRNA synthetase complex interacting multifunctional protein 2
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Cytoplasm Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Protein-macromolecule Adaptor Activity Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Germ Cell Development Nervous System Development Visual Learning Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Development	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Protein Ubiquitination Cell Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Type II Pneumocyte Differentiation Protein-containing Complex Assembly
Pathways			Selenoamino acid metabolism Cytosolic tRNA aminoacylation Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		23 interacting genes: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A CEP76 FHL1 FXR1 FXR2 GSK3A GSK3B HRAS INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B RIDA TK1 XRCC5 XRCC6	103 interacting genes: AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CEBPA CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DRC12 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FILNC1 FUBP1 GYS1 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT
Entrez ID		10522	7965
HPRD ID		04027	02915
Ensembl ID		ENSG00000177030	ENSG00000106305
Uniprot IDs		A0A804HIS1 O75398	A8MU58 Q13155
PDB IDs		2JW6 4A24 5UWW	4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39 8J9S 9DPL
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Cytosol Regulation Of Phosphorus Metabolic Process Cellular Response To Gamma Radiation Regulation Of Phosphorylation Oncogene-induced Cell Senescence Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Catalytic Activity Postsynapse Regulation Of Protein Phosphorylation Response To Gamma Radiation Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Glycogen Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA End Binding Ku70:Ku80 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Cell Development Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Presynapse Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Kinase Activity DNA-dependent Protein Kinase Complex Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Extracellular Vesicle Negative Regulation Of Gene Expression MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Translation Regulation Of MRNA Stability Regulation Of Angiogenesis Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Regulation Of Vasculature Development Regulation Of RNA Stability Negative Regulation Of Cytokine Production Negative Regulation Of Signal Transduction Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Catabolic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Sprouting Angiogenesis Extracellular Space Regulation Of Macromolecule Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of MRNA Metabolic Process Negative Regulation Of Cell Migration Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cell Motility
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