DEAF1 and ASCC2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DEAF1	ASCC2
Description		DEAF1 transcription factor	activating signal cointegrator 1 complex subunit 2
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GO Annotations	Cellular Component	Chromatin Fibrillar Center Extracellular Region Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Nuclear Speck Cytosolic Ribosome RQC-trigger Complex DNA Repair Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Protein Binding Ubiquitin Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Germ Cell Development Nervous System Development Visual Learning Anatomical Structure Morphogenesis Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Embryonic Skeletal System Development	DNA Replication DNA Repair DNA Alkylation Repair Regulation Of DNA-templated Transcription DNA Damage Response Ribosome Disassembly Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways			ALKBH3 mediated reversal of alkylation damage ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS			Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Crohn's disease ( 28067908) Hemoglobin levels ( 32327693) IgA levels ( 28628107) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin concentration ( 32888494) Refractive error ( 32231278) Spleen volume ( 34128465) Telomere length ( 24478790) Tonsillectomy ( 27941131) Type 2 diabetes ( 30297969) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		23 interacting genes: AIMP2 ASCC2 CDC37 CDKN1A CDKN2A CEP76 FHL1 FXR1 FXR2 GSK3A GSK3B HRAS INTS1 LMO4 PELI2 PIN1 PPP1CA PPP1CC RAD23B RIDA TK1 XRCC5 XRCC6	41 interacting genes: ASS1 CKAP4 CUTC DEAF1 EEF1D ELAC2 FAF1 FBP1 FUNDC2 GADD45A GFER GNL3 GTF3C1 IGSF9 IMMT KATNAL1 KDM1A LPL MAP3K1 MED31 MYH9 OLA1 PCBD2 PIK3CD PIN4 PJA1 POLA2 POLDIP2 PRPF18 RADIL RNF11 RPA1 RPLP1 SASH1 SMURF1 SNRPB SNW1 TBC1D17 TRIP4 UBC URM1
Entrez ID		10522	84164
HPRD ID		04027	16515
Ensembl ID		ENSG00000177030	ENSG00000100325
Uniprot IDs		A0A804HIS1 O75398	Q9H1I8
PDB IDs		2JW6 4A24 5UWW	2DI0 6YXQ
Enriched GO Terms of Interacting Partners?		Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Modification Process Cytosol Regulation Of Phosphorus Metabolic Process Cellular Response To Gamma Radiation Regulation Of Phosphorylation Oncogene-induced Cell Senescence Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Catalytic Activity Postsynapse Regulation Of Protein Phosphorylation Response To Gamma Radiation Positive Regulation Of Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Metabolic Process Glycogen Metabolic Process Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Ionizing Radiation Energy Reserve Metabolic Process Polysaccharide Metabolic Process Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA End Binding Ku70:Ku80 Complex Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Macromolecule Metabolic Process Regulation Of Glycogen Biosynthetic Process Regulation Of Cell Development Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of RNA Metabolic Process Positive Regulation Of Protein Phosphorylation Presynapse Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Protein Kinase Activity DNA-dependent Protein Kinase Complex Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Regulation Of Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process	Macromolecule Metabolic Process Nucleoplasm
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