SNX5 and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		SNX5	LAMTOR5
Description		sorting nexin 5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Image
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Brush Border Cytoplasmic Side Of Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Cytoplasmic Vesicle Early Endosome Membrane Cell Projection Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome Cytoplasmic Side Of Early Endosome Membrane	Cytoplasm Lysosome Lysosomal Membrane Cytosol Late Endosome Membrane Protein-containing Complex Ragulator Complex FNIP-folliculin RagC/D GAP
	Molecular Function	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Intracellular Protein Transport Endocytosis Pinocytosis Epidermal Growth Factor Catabolic Process Protein Transport Regulation Of Macroautophagy Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of DNA-templated Transcription Positive Regulation Of Insulin Receptor Signaling Pathway	Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Viral Genome Replication Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-8 Production TORC1 Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling
Pathways		Golgi Associated Vesicle Biogenesis	Macroautophagy MTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Liver enzyme levels (alanine transaminase) ( 33972514) Low density lipoprotein cholesterol levels ( 33339817)
Interacting Genes		21 interacting genes: APPBP2 AQP2 BANP CDC37 CLTC CLTCL1 DNAJB11 DSCR9 FANCA HGS HMOX2 ITSN1 LAMTOR5 MESD MIB1 NRP1 OGT PFDN1 PRKRA PSMB8 RIGI	63 interacting genes: ACAA2 AKR1C2 ALB ANKRD46 ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLIC5 DBI DNAJA3 ECT2 EEF1A1 EIF3A EIF4B GAPDH GIT1 GIT2 GPRASP1 HEBP2 HSPA9 ITGB1 KEAP1 KIF1B KMT2E LRIF1 MAF1 MCPH1 MED12L MEOX2 MKLN1 MT2A MYF6 MYH3 MYOG NCOA6 PDK1 PEG10 PPARA RABIF RBP4 SERPINA1 SFPQ SHB SKP1 SMAD4 SNX5 TAF9 TBC1D4 TCAP TCF12 TGFB1 TOP2B TP53 TRIM55 TRIM63 UTP14A YTHDC1 ZBTB16 ZNF592
Entrez ID		27131	10542
HPRD ID		10439	09773
Ensembl ID		ENSG00000089006	ENSG00000134248
Uniprot IDs		Q6P5V6 Q9Y5X3	A0A8Z5A536 O43504
PDB IDs		1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z 8A1G 8ABQ 8AFZ	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 5YK5 6B9X 6EHP 6EHR 6NZD 6U62 6ULG 6WJ2 6WJ3 7T3A 7T3B 7T3C 7UX2 7UXC 7UXH 8DHB
Enriched GO Terms of Interacting Partners?		Cytoplasmic Vesicle Membrane Clathrin Coat Of Trans-Golgi Network Vesicle Endocytosis Clathrin Complex Receptor-mediated Endocytosis Clathrin Light Chain Binding Sorting Endosome Protein Localization To Lysosome Import Into Cell Double-stranded RNA Binding Clathrin-coated Pit Protein Folding Intracellular Protein Localization Protein Localization To Vacuole Cytoplasm Endosomal Transport Clathrin-coated Endocytic Vesicle Unfolded Protein Binding Cytoplasmic Vesicle Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Clathrin-dependent Endocytosis Protein Folding Chaperone Complex Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Otic Placode Development Basal Dendrite Development	Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Animal Organ Development Negative Regulation Of Glycolytic Process Regulation Of Primary Metabolic Process Positive Regulation Of RNA Biosynthetic Process Glucose Metabolic Process Muscle Organ Development Regulation Of Skeletal Muscle Tissue Development Regulation Of Carbohydrate Catabolic Process Negative Regulation Of ATP Metabolic Process Disordered Domain Specific Binding Cell Activation Centrosome Striated Muscle Tissue Development RNA Polymerase II Transcription Regulator Complex Regulation Of Nucleobase-containing Compound Metabolic Process Response To Muscle Activity Muscle Structure Development Muscle Tissue Morphogenesis Negative Regulation Of Growth Regulation Of MiRNA Transcription Protein Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Small Molecule Metabolic Process Leukocyte Activation Positive Regulation Of RNA Metabolic Process Muscle Tissue Development Regulation Of Purine Nucleotide Metabolic Process Striated Muscle Atrophy Regulation Of Muscle Cell Differentiation Lymphocyte Activation Lymphocyte Differentiation Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of DNA-templated Transcription Hexose Metabolic Process Protein-containing Complex Binding Germ Cell Migration Regulation Of MiRNA Metabolic Process Anterior/posterior Pattern Specification Positive Regulation Of Skeletal Muscle Fiber Development Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Sarcomere Organization Regulation Of Striated Muscle Tissue Development Muscle Atrophy Heart Development Identical Protein Binding
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