SNX5 and PRKRA

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		SNX5	PRKRA
Gene Name		sorting nexin 5	protein kinase, interferon-inducible double stranded RNA dependent activator
Image
Gene Ontology Annotations	Cellular Component	Ruffle Phagocytic Cup Cytoplasmic Vesicle Membrane Retromer Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Macropinocytic Cup Tubular Endosome	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Dynactin Binding Phosphatidylinositol Binding	Protein Binding Enzyme Activator Activity Protein Homodimerization Activity Poly(A) RNA Binding
	Biological Process	Intracellular Protein Transport Pinocytosis Vesicle Organization Retrograde Transport, Endosome To Golgi	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Production Of SiRNA Involved In RNA Interference Cellular Response To Oxidative Stress Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding	Regulatory RNA pathways MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
Drugs
Diseases
GWAS			Multiple sclerosis (OCB status) ( 23472185)
Protein-Protein Interactions		14 interactors: APPBP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESDC2 MIB1 PFDN1 PRKRA SNX2	21 interactors: AGO2 CEBPZ COPS6 DICER1 EIF2AK2 GDF9 KIAA1377 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746
Entrez ID		27131	8575
HPRD ID		10439	04573
Ensembl ID		ENSG00000089006	ENSG00000180228
Uniprot IDs		Q6P5V6 Q9Y5X3	B4DJC7 O75569
PDB IDs		1SYS	2DIX
Enriched GO Terms of Interacting Partners?		Cellular Protein Localization Intracellular Protein Transport Cellular Localization Protein Folding Endocytosis Protein Localization Establishment Of Localization In Cell Protein Transport Establishment Of Protein Localization Intracellular Transport Transport Vesicle-mediated Transport Developmental Process Negative Regulation Of Hyaluronan Biosynthetic Process Heme Oxidation Anatomical Structure Development Lamellipodium Morphogenesis	RNA Interference Pre-miRNA Processing Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Posttranscriptional Regulation Of Gene Expression RNA Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Silencing By MiRNA Targeting Of MRNA For Destruction Involved In RNA Interference Cellular Response To DsRNA Regulation Of Gene Expression Posttranscriptional Gene Silencing Gene Expression Production Of SiRNA Involved In RNA Interference Regulation Of Transcription, DNA-templated Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Viral Process Negative Regulation Of Biosynthetic Process RNA Biosynthetic Process Gene Silencing By RNA Glial Cell Apoptotic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To DsRNA Regulation Of Viral Genome Replication Regulation Of Protein Metabolic Process Regulation Of Translational Initiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of MRNA 3'-end Processing Gene Silencing Regulation Of Translation Viral Process Regulation Of Metabolic Process Regulation Of MRNA 3'-end Processing ER-nucleus Signaling Pathway Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Growth Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation
Tagcloud ?		counteracted egf egfr endosomal endosomes escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting sorting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular	1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Difference) ?		counteracted egf egfr endosomal endosomes escrt generating ilvs intraluminal laptm4b lysosomal machineries mves neutralizes oncoprotein p2 pip pipkigammai5 promoting ptdins recruiting sorting termination transform transmembrane ubiquitinated ubiquitination vesicles vesicular	1q21 5q31 6p21 alleles anxa6 applicable atopic conduct dermatitis direction exclusive histocompatibility immunochip influencing loci methodologies mutually opposing overlap overlapping pleiotropic psoriasis rarely shared th2 tnip1 traits unreported utilizing
Tagcloud (Intersection) ?