PPIH and LNX2

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		PPIH	LNX2
Description		peptidylprolyl isomerase H	ligand of numb-protein X 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP	Plasma Membrane
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity Ribonucleoprotein Complex Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding PDZ Domain Binding Identical Protein Binding Metal Ion Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication Protein-containing Complex Assembly	Nervous System Development Neuron Differentiation Neural Precursor Cell Proliferation
Pathways		mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses
Drugs		Proline
Diseases
GWAS			Age at first sexual intercourse ( 34211149) Body mass index ( 26426971 28892062) Large B-cell lymphoma ( 21471979) Mean platelet volume ( 27863252 32888494) Night sleep phenotypes ( 27126917) Platelet distribution width ( 27863252 32888494) Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		14 interacting genes: BAG2 BPIFA1 CEBPA DOK3 LNX1 LNX2 N4BP2L2 NIF3L1 PRPF18 PRPF31 PRPF4 SNU13 UBQLN2 XIAP	90 interacting genes: ATP5F1B C10orf88 CABP4 CBX4 CCT3 CDK2 CDK4 CDKN2C CRK CXADR DDA1 DRAP1 EAF2 FANCG FHL3 GADD45A GJD2 GLRX3 GRAP2 GRB2 IGSF5 IL16 INMT IP6K2 L3MBTL2 LGALS14 LNX1 LRRC8E MAP2K5 MAPK9 MCM7 MDGA1 MECOM MLX MRFAP1L1 MSRB3 MYLIP NAGK NMD3 NOTCH1 NTAQ1 NUDT14 NUMB OPTN PARVG PDZRN3 PDZRN4 PEG10 PHYKPL PIK3R1 PIK3R3 PKDREJ POLR1C PPIH PPIL1 PSMD5 PSMF1 PTCD3 RAB6B RBM17 RLIM RNF138 ROPN1 RPA2 SCLY SCNM1 SFN SH3GLB2 SHISA2 SHTN1 SMARCB1 SRSF11 TAB1 TBC1D7 TCL1A TIFA TRAF1 TRAF2 TUBB UBE2D2 UBE2H UBE2I UBE2T UBE2Z USP2 VTN YJU2 ZNF148 ZNF410 ZNF581
Entrez ID		10465	222484
HPRD ID		12084	10042
Ensembl ID		ENSG00000171960	ENSG00000139517
Uniprot IDs		O43447 Q6FH36	Q8N448
PDB IDs		1MZW 1QOI 5O9Z 6AHD 8H6K 8H6L 8QO9 8QZS 8R09 8R0B 8RM5	2VWR 5DIN 5E11 5E1Y 5E21 5E22 7QCT
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex U4 SnRNA Binding U4atac SnRNP U4atac SnRNA Binding U2-type Precatalytic Spliceosome Spliceosomal Complex Identical Protein Binding Regulation Of Hematopoietic Stem Cell Proliferation Precatalytic Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Splicing Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process MRNA Splicing, Via Spliceosome MRNA Processing Protein-RNA Complex Assembly Box C/D Sno(s)RNA Binding RNA Splicing, Via Transesterification Reactions U2-type Post-spliceosomal Complex Histone H3K36me2/H3K36me3 Demethylase Activity Ribonucleoprotein Complex Localization Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Ubiquitin-protein Transferase Activity Response To Vitamin B2 C/EBP Complex Dense Fibrillar Component Generation Of Catalytic Spliceosome For Second Transesterification Step Cajal Body Negative Regulation Of G Protein-coupled Receptor Internalization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism MRNA Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation U4/U6 SnRNP Dendritic Microtubule SnRNP Binding PDZ Domain Binding White Fat Cell Proliferation Spliceosomal SnRNP Complex Histone H3K9me2/H3K9me3 Demethylase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Immune Response In Gut-associated Lymphoid Tissue Regulation Of Protein Catabolic Process	Nucleoplasm Phosphotyrosine Residue Binding Post-translational Protein Modification Nucleus Protein Modification By Small Protein Conjugation Ubiquitin Conjugating Enzyme Activity Cytosol Ubiquitin-protein Transferase Activity Cellular Response To Nitric Oxide Cellular Response To Reactive Nitrogen Species Nuclear Speck Protein Ubiquitination Identical Protein Binding Response To Nitric Oxide Transferase Activity Cytoplasm
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