PPIH and PRPF4

Number of citations of the paper that reports this interaction (PubMedID 12907720)
29

Data Source:
HPRD (in vitro)

		PPIH	PRPF4
Description		peptidylprolyl isomerase H	pre-mRNA splicing tri-snRNP complex factor PRPF4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytosol Nuclear Speck Intracellular Membrane-bounded Organelle U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex
	Molecular Function	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Cyclosporin A Binding Isomerase Activity Ribonucleoprotein Complex Binding	Protein Binding U6 SnRNA Binding U4 SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Protein Folding RNA Splicing Positive Regulation Of Viral Genome Replication Protein-containing Complex Assembly	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Major Pathway SARS-CoV-1 activates/modulates innate immune responses	mRNA Splicing - Major Pathway
Drugs		Proline
Diseases
GWAS			White matter growth ( 29682794)
Interacting Genes		14 interacting genes: BAG2 BPIFA1 CEBPA DOK3 LNX1 LNX2 N4BP2L2 NIF3L1 PRPF18 PRPF31 PRPF4 SNU13 UBQLN2 XIAP	10 interacting genes: APP ATP5MF CEBPA CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4
Entrez ID		10465	9128
HPRD ID		12084	08479
Ensembl ID		ENSG00000171960	ENSG00000136875
Uniprot IDs		O43447 Q6FH36	O43172 Q5T1M7
PDB IDs		1MZW 1QOI 5O9Z 6AHD 8H6K 8H6L 8QO9 8QZS 8R09 8R0B 8RM5	1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9 8H6E 8H6J 8H6K 8H6L 8Q7N 8QO9 8QOZ 8QPA 8QPB 8QPE 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 8Y6O
Enriched GO Terms of Interacting Partners?		U4/U6 X U5 Tri-snRNP Complex U4 SnRNA Binding U4atac SnRNP U4atac SnRNA Binding U2-type Precatalytic Spliceosome Spliceosomal Complex Identical Protein Binding Regulation Of Hematopoietic Stem Cell Proliferation Precatalytic Spliceosome Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process RNA Splicing Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Protein Catabolic Process MRNA Splicing, Via Spliceosome MRNA Processing Protein-RNA Complex Assembly Box C/D Sno(s)RNA Binding RNA Splicing, Via Transesterification Reactions U2-type Post-spliceosomal Complex Histone H3K36me2/H3K36me3 Demethylase Activity Ribonucleoprotein Complex Localization Positive Regulation Of Protein Linear Polyubiquitination Regulation Of Apoptosis Involved In Tissue Homeostasis Ubiquitin-protein Transferase Activity Response To Vitamin B2 C/EBP Complex Dense Fibrillar Component Generation Of Catalytic Spliceosome For Second Transesterification Step Cajal Body Negative Regulation Of G Protein-coupled Receptor Internalization Immune Response In Nasopharyngeal-associated Lymphoid Tissue Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism MRNA Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Regulation Of Stem Cell Proliferation U4/U6 SnRNP Dendritic Microtubule SnRNP Binding PDZ Domain Binding White Fat Cell Proliferation Spliceosomal SnRNP Complex Histone H3K9me2/H3K9me3 Demethylase Activity Negative Regulation Of Hematopoietic Stem Cell Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Immune Response In Gut-associated Lymphoid Tissue Regulation Of Protein Catabolic Process	Spliceosomal Complex RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Splicing MRNA Processing RS Domain Binding MRNA Metabolic Process RNA Metabolic Process RNA Processing Nuclear Speck Nucleobase-containing Compound Metabolic Process Nucleic Acid Binding Nucleic Acid Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Gland Development Animal Organ Regeneration RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Acetylcholine Receptor Activator Activity Macromolecule Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Nucleus Regulation Of Stem Cell Proliferation Response To Vitamin B2 C/EBP Complex Protein Localization To P-body Catalytic Step 2 Spliceosome Vascular Endothelial Cell Proliferation Epicardium Morphogenesis PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization CHOP-C/EBP Complex Liver Development Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis Transforming Growth Factor Beta Ligand-receptor Complex U4/U6 SnRNP Notch Signaling Pathway Response To Norepinephrine
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