RTN3 and MAP1LC3A

Number of citations: 66 (PubMedID 37219487)
Data Source: BioGRID (unspecified method)

		RTN3	MAP1LC3A
Name		reticulon 3	microtubule associated protein 1 light chain 3 alpha
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Neuron Projection Synapse	Autophagosome Membrane Cytoplasm Late Endosome Autophagosome Cytosol Cytoskeleton Microtubule Endomembrane System Membrane Organelle Membrane Cytoplasmic Vesicle Autolysosome Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding	Protein Binding Phospholipid Binding Microtubule Binding Phosphatidylethanolamine Binding Ubiquitin Protein Ligase Binding
	Biological Process	Apoptotic Process Brain Development Vesicle-mediated Transport Neuron Differentiation Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization	Autophagosome Assembly Autophagy Of Mitochondrion Mitophagy Autophagy Cellular Response To Nitrogen Starvation JNK Cascade Cellular Response To Starvation Response To Iron(II) Ion Response To Lead Ion Macroautophagy Response To Nutrient Levels Cellular Response To Amino Acid Starvation P38MAPK Cascade SMAD Protein Signal Transduction Cellular Response To Hydrogen Peroxide Cellular Response To Copper Ion Cellular Response To Oxygen-glucose Deprivation Autophagosome Maturation
Pathways		Synaptic adhesion-like molecules	Macroautophagy PINK1-PRKN Mediated Mitophagy Receptor Mediated Mitophagy
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 ) Bipolar disorder ( 31043756 ) Colorectal cancer or advanced adenoma ( 30510241 ) Fish- and plant-related diet ( 32066663 ) Hip circumference adjusted for BMI ( 34021172 ) Oily fish consumption ( 32066663 ) Pork consumption ( 32066663 )
Interacting Genes		32 interacting genes: AGTR1 CCR2 CCR8 CDIPT CERT1 DRD2 FGFR1 FHIP1B FXR2 GLP1R GPR152 GPR35 LMNA MAP1LC3A MITD1 NDRG4 PLEKHF2 PLN PPP2R3C PTPN9 RAB33A RMDN2 RTN4 SACM1L SHANK3 SLC30A3 SLC30A8 SNX1 SPOP TERF1 UGCG ZNF391	100 interacting genes: ABTB3 AKAP13 AMBRA1 ANK2 ANK3 ANKRD62 AP5B1 APOBR APP APPL1 ARHGAP6 ATF7IP2 ATG13 ATG2A ATG4B ATG7 ATXN3 BCL9 BNIP3L BRD9 CAMSAP1 CARS2 CCPG1 CDC37 CSAG1 DPPA4 DVL2 EPHA7 FUNDC1 GPSM1 HTATSF1 IRGQ IRS4 KIF15 KXD1 LINC00696 LMNB1 MAP1A MAP1S MAVS MDM2 MEFV MREG MRTFA MTX1 MYBPC1 NBR1 NCOR1 NEDD4 NEDD4L NEK9 NEURL4 OPRM1 OPTN PCNT PHB1 PIAS4 PRPF40A RABGAP1 RABGAP1L RASAL3 RDH12 RELB RESF1 RETREG3 RIC1 RTKN RTN3 SEC62 SLA2 SP1 SP3 SRPK1 STBD1 STK10 TBC1D1 TBC1D10A TBC1D10B TBC1D16 TBC1D17 TBC1D2 TBC1D25 TBC1D2B TBC1D5 TBC1D7 TBC1D9 TBC1D9B TMEM132C TNIP1 TP53INP1 TP53INP2 TRIM21 TRIM25 TRIM32 TTN TUBA4A VPS9D1 ZBTB48 ZKSCAN4 ZNF304
Entrez ID		10313	84557
HPRD ID		18516	03144
Ensembl ID		ENSG00000133318	ENSG00000101460
Uniprot IDs		O95197	Q9H492
PDB IDs		7BRU	3ECI 3WAL 3WAN 4ZDV 5CX3 5DPR 6TBE 7R9W 7R9Z 7RA0 8T2L 8T35 8T36 8T4T
GO Terms Enriched among Interactors		Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Chemokine Receptor Activity Orbitofrontal Cortex Development Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Regulation Of Biological Quality Associative Learning Identical Protein Binding Regulation Of System Process Regulation Of Synapse Structural Plasticity G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Response To Zinc Ion Membrane Learning Or Memory Visual Learning Golgi Apparatus Zinc Ion Import Into Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Visual Behavior Learning Regulation Of Glutamate Receptor Signaling Pathway Calcium-mediated Signaling System Process Auditory Behavior Cognition Protein Homodimerization Activity Response To Metal Ion Regulation Of Synaptic Transmission, Glutamatergic Mechanosensory Behavior Chemokine-mediated Signaling Pathway Organelle Organization Monoatomic Cation Transmembrane Transporter Activity Homeostatic Process Glutamatergic Synapse Signal Transduction C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Dephosphorylation Calcium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Regulation Of Blood Circulation Regulation Of Hormone Secretion Cell Migration Angiotensin Type I Receptor Activity Response To Iron Ion	Autophagosome GTPase Activator Activity Regulation Of Cilium Assembly Autophagy Macroautophagy Positive Regulation Of Catabolic Process Positive Regulation Of Autophagy Regulation Of Organelle Assembly Autophagosome Assembly Regulation Of Cell Projection Organization Autophagosome Organization Regulation Of Cell Projection Assembly Cytoplasmic Vesicle Regulation Of Autophagy Regulation Of Plasma Membrane Bounded Cell Projection Organization Autophagy Of Mitochondrion Organelle Organization Cytosol Vacuole Organization Mitophagy Positive Regulation Of Macroautophagy Regulation Of Macroautophagy Regulation Of Cellular Component Organization Piecemeal Microautophagy Of The Nucleus Regulation Of Organelle Organization Microautophagy Nucleophagy Positive Regulation Of Metabolic Process Substrate Localization To Autophagosome M Band Cytoskeleton Organization Phagophore Assembly Site Vesicle-mediated Transport Transcription Repressor Complex Intracellular Protein Localization Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Microtubule Associated Complex Regulation Of Protein Localization Negative Regulation Of Viral Process Catabolic Process Protein Kinase Regulator Activity Suppression Of Viral Release By Host Regulation Of Viral Process Regulation Of GTPase Activity Cytoplasm Ubiquitin Protein Ligase Activity Positive Regulation Of Protein Catabolic Process Cytoskeletal Anchor Activity Protein-macromolecule Adaptor Activity