RTN3 and AKAP8

Data Source: HiPPIP (Novel)

		RTN3	AKAP8
Name		reticulon 3	A-kinase anchoring protein 8
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Neuron Projection Synapse	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Nuclear Matrix
	Molecular Function	Protein Binding	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding NF-kappaB Binding
	Biological Process	Apoptotic Process Brain Development Vesicle-mediated Transport Neuron Differentiation Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization	Mitotic Cell Cycle Immune System Process Mitotic Chromosome Condensation Signal Transduction Protein Transport Negative Regulation Of Tumor Necrosis Factor Production Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus
Pathways		Synaptic adhesion-like molecules	None
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		1 novel interactors: AKAP8	6 novel interactors: B3GNT3 CELF3 CNN1 ELK1 RTN3 ZNHIT1
Interacting Genes		32 interacting genes: AGTR1 CCR2 CCR8 CDIPT CERT1 DRD2 FGFR1 FHIP1B FXR2 GLP1R GPR152 GPR35 LMNA MAP1LC3A MITD1 NDRG4 PLEKHF2 PLN PPP2R3C PTPN9 RAB33A RMDN2 RTN4 SACM1L SHANK3 SLC30A3 SLC30A8 SNX1 SPOP TERF1 UGCG ZNF391	12 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 FILNC1 MCM2 PRKAR2A RELA RNF10
Entrez ID		10313	10270
HPRD ID		18516	05258
Ensembl ID		ENSG00000133318	ENSG00000105127
Uniprot IDs		O95197	O43823
PDB IDs		7BRU	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Chemokine Receptor Activity Orbitofrontal Cortex Development Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Regulation Of Biological Quality Associative Learning Identical Protein Binding Regulation Of System Process Regulation Of Synapse Structural Plasticity G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Response To Zinc Ion Membrane Learning Or Memory Visual Learning Golgi Apparatus Zinc Ion Import Into Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Visual Behavior Learning Regulation Of Glutamate Receptor Signaling Pathway Calcium-mediated Signaling System Process Auditory Behavior Cognition Protein Homodimerization Activity Response To Metal Ion Regulation Of Synaptic Transmission, Glutamatergic Mechanosensory Behavior Chemokine-mediated Signaling Pathway Organelle Organization Monoatomic Cation Transmembrane Transporter Activity Homeostatic Process Glutamatergic Synapse Signal Transduction C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Dephosphorylation Calcium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Regulation Of Blood Circulation Regulation Of Hormone Secretion Cell Migration Angiotensin Type I Receptor Activity Response To Iron Ion	Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Response To X-ray Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Amyloid-beta Formation Postsynapse To Nucleus Signaling Pathway Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Cell Cycle G1/S Phase Transition Protein Serine/threonine Kinase Activator Activity Response To Radiation Regulation Of Amide Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Organizing Center Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Pre-mRNA Binding Liver Development Positive Regulation Of Amyloid-beta Formation Response To Ethanol Positive Regulation Of Cell Cycle Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Histone Deacetylase Binding Positive Regulation Of Mitotic Cell Cycle Response To Light Stimulus Positive Regulation Of Amyloid Precursor Protein Catabolic Process Execution Phase Of Apoptosis Negative Regulation Of Cell Cycle Positive Regulation Of Amide Metabolic Process Mitotic Cell Cycle Phase Transition Response To UV Regulation Of Cell Cycle Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Enzyme Binding Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Process Regulation Of Primary Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Response To Nicotine Regulation Of Cell Cycle Phase Transition MiRNA Transcription Protein Kinase Binding Postsynaptic Signal Transduction Response To Steroid Hormone Response To Ketone