RTN3 and ZNF391

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		RTN3	ZNF391
Name		reticulon 3	zinc finger protein 391
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Neuron Projection Synapse	Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Apoptotic Process Brain Development Vesicle-mediated Transport Neuron Differentiation Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Synaptic adhesion-like molecules	None
GWAS		No GWAS studies recorded	Aspartate aminotransferase levels ( 33547301 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Brain morphology (MOSTest) ( 32665545 ) Feeling nervous ( 29500382 ) Fish- and plant-related diet ( 32066663 ) Liver iron content ( 34128465 ) Refractive error ( 32231278 ) Serum alkaline phosphatase levels ( 33547301 ) Subcortical volume (MOSTest) ( 32665545 )
Interacting Genes		32 interacting genes: AGTR1 CCR2 CCR8 CDIPT CERT1 DRD2 FGFR1 FHIP1B FXR2 GLP1R GPR152 GPR35 LMNA MAP1LC3A MITD1 NDRG4 PLEKHF2 PLN PPP2R3C PTPN9 RAB33A RMDN2 RTN4 SACM1L SHANK3 SLC30A3 SLC30A8 SNX1 SPOP TERF1 UGCG ZNF391	5 interacting genes: AGTRAP ARL6IP1 CMTM5 LDAF1 RTN3
Entrez ID		10313	346157
HPRD ID		18516	18893
Ensembl ID		ENSG00000133318	ENSG00000124613
Uniprot IDs		O95197	Q9UJN7
PDB IDs		7BRU	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Chemokine Receptor Activity Orbitofrontal Cortex Development Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Regulation Of Biological Quality Associative Learning Identical Protein Binding Regulation Of System Process Regulation Of Synapse Structural Plasticity G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Response To Zinc Ion Membrane Learning Or Memory Visual Learning Golgi Apparatus Zinc Ion Import Into Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Visual Behavior Learning Regulation Of Glutamate Receptor Signaling Pathway Calcium-mediated Signaling System Process Auditory Behavior Cognition Protein Homodimerization Activity Response To Metal Ion Regulation Of Synaptic Transmission, Glutamatergic Mechanosensory Behavior Chemokine-mediated Signaling Pathway Organelle Organization Monoatomic Cation Transmembrane Transporter Activity Homeostatic Process Glutamatergic Synapse Signal Transduction C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Dephosphorylation Calcium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Regulation Of Blood Circulation Regulation Of Hormone Secretion Cell Migration Angiotensin Type I Receptor Activity Response To Iron Ion	Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Endoplasmic Reticulum Positive Regulation Of L-glutamate Import Across Plasma Membrane Angiotensin Type II Receptor Activity Regulation Of Endoplasmic Reticulum Tubular Network Organization Sec61 Translocon Complex Regulation Of L-glutamate Import Across Plasma Membrane Cotranslational Protein Targeting To Membrane Lipid Droplet Formation Endoplasmic Reticulum Tubular Network Positive Regulation Of Amino Acid Transport Angiotensin-activated Signaling Pathway Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Myoblast Differentiation