RTN3 and PPP2R3C

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		RTN3	PPP2R3C
Name		reticulon 3	protein phosphatase 2 regulatory subunit B''gamma
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Neuron Projection Synapse	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cilium Actin Cytoskeleton Nuclear Body
	Molecular Function	Protein Binding	Protein Binding Metal Ion Binding
	Biological Process	Apoptotic Process Brain Development Vesicle-mediated Transport Neuron Differentiation Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization	Microtubule Cytoskeleton Organization B Cell Homeostasis Regulation Of Antimicrobial Humoral Response Cortical Cytoskeleton Organization Regulation Of Dephosphorylation T Cell Homeostasis Positive Regulation Of B Cell Differentiation Spleen Development Regulation Of B Cell Activation Regulation Of Mitochondrial Depolarization
Pathways		Synaptic adhesion-like molecules	None
GWAS		No GWAS studies recorded	Atopic dermatitis ( 26482879 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025 ) Lymphocyte count ( 27863252 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Neutrophil percentage of white cells ( 32888494 )
Interacting Genes		32 interacting genes: AGTR1 CCR2 CCR8 CDIPT CERT1 DRD2 FGFR1 FHIP1B FXR2 GLP1R GPR152 GPR35 LMNA MAP1LC3A MITD1 NDRG4 PLEKHF2 PLN PPP2R3C PTPN9 RAB33A RMDN2 RTN4 SACM1L SHANK3 SLC30A3 SLC30A8 SNX1 SPOP TERF1 UGCG ZNF391	15 interacting genes: CCDC146 CCDC33 CMTM5 ENKD1 FAM161A FAM161B HSPB1 IKBKB MOAP1 MTNR1A POLR1C PRPF31 RTN3 SMG9 TRIM14
Entrez ID		10313	55012
HPRD ID		18516	12622
Ensembl ID		ENSG00000133318	ENSG00000092020
Uniprot IDs		O95197	Q969Q6
PDB IDs		7BRU	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Chemokine Receptor Activity Orbitofrontal Cortex Development Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Regulation Of Biological Quality Associative Learning Identical Protein Binding Regulation Of System Process Regulation Of Synapse Structural Plasticity G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Response To Zinc Ion Membrane Learning Or Memory Visual Learning Golgi Apparatus Zinc Ion Import Into Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Visual Behavior Learning Regulation Of Glutamate Receptor Signaling Pathway Calcium-mediated Signaling System Process Auditory Behavior Cognition Protein Homodimerization Activity Response To Metal Ion Regulation Of Synaptic Transmission, Glutamatergic Mechanosensory Behavior Chemokine-mediated Signaling Pathway Organelle Organization Monoatomic Cation Transmembrane Transporter Activity Homeostatic Process Glutamatergic Synapse Signal Transduction C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Dephosphorylation Calcium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Regulation Of Blood Circulation Regulation Of Hormone Secretion Cell Migration Angiotensin Type I Receptor Activity Response To Iron Ion	None