RTN3 and UGCG

Number of citations: 0 (PubMedID 12873973)
Data Source: HPRD (two hybrid)

		RTN3	UGCG
Name		reticulon 3	UDP-glucose ceramide glucosyltransferase
Structure			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Postsynaptic Density Membrane Neuron Projection Synapse	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding	Protein Binding Ceramide Glucosyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Apoptotic Process Brain Development Vesicle-mediated Transport Neuron Differentiation Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Negative Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Tubular Network Membrane Organization	Protein Lipidation Lipid Metabolic Process Sphingolipid Metabolic Process Glucosylceramide Biosynthetic Process Glycosphingolipid Biosynthetic Process Epidermis Development Regulation Of Signal Transduction Cell Differentiation Keratinocyte Differentiation Leptin-mediated Signaling Pathway Neuron Development Establishment Of Skin Barrier Intestinal Lipid Absorption Cornified Envelope Assembly
Pathways		Synaptic adhesion-like molecules	Glycosphingolipid biosynthesis
Drugs		None	Miglustat Eliglustat
GWAS		No GWAS studies recorded	Benign prostatic hyperplasia ( 30988330 ) Mean corpuscular hemoglobin ( 32888494 ) Metabolite levels ( 23823483 ) Red blood cell count ( 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )
Interacting Genes		32 interacting genes: AGTR1 CCR2 CCR8 CDIPT CERT1 DRD2 FGFR1 FHIP1B FXR2 GLP1R GPR152 GPR35 LMNA MAP1LC3A MITD1 NDRG4 PLEKHF2 PLN PPP2R3C PTPN9 RAB33A RMDN2 RTN4 SACM1L SHANK3 SLC30A3 SLC30A8 SNX1 SPOP TERF1 UGCG ZNF391	3 interacting genes: APP RTN1 RTN3
Entrez ID		10313	7357
HPRD ID		18516	04190
Ensembl ID		ENSG00000133318	ENSG00000148154
Uniprot IDs		O95197	Q16739
PDB IDs		7BRU	Not available
GO Terms Enriched among Interactors		Positive Regulation Of Cytosolic Calcium Ion Concentration G Protein-coupled Receptor Activity Chemokine Receptor Activity Orbitofrontal Cortex Development Regulation Of Long-term Neuronal Synaptic Plasticity Intracellular Signaling Cassette Regulation Of Biological Quality Associative Learning Identical Protein Binding Regulation Of System Process Regulation Of Synapse Structural Plasticity G Protein-coupled Receptor Signaling Pathway Regulation Of Renal Sodium Excretion Response To Zinc Ion Membrane Learning Or Memory Visual Learning Golgi Apparatus Zinc Ion Import Into Organelle Positive Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Neuronal Synaptic Plasticity Visual Behavior Learning Regulation Of Glutamate Receptor Signaling Pathway Calcium-mediated Signaling System Process Auditory Behavior Cognition Protein Homodimerization Activity Response To Metal Ion Regulation Of Synaptic Transmission, Glutamatergic Mechanosensory Behavior Chemokine-mediated Signaling Pathway Organelle Organization Monoatomic Cation Transmembrane Transporter Activity Homeostatic Process Glutamatergic Synapse Signal Transduction C-C Chemokine Binding C-C Chemokine Receptor Activity Positive Regulation Of Long-term Synaptic Potentiation Regulation Of Dephosphorylation Calcium Ion Homeostasis Zinc Ion Transmembrane Transporter Activity Regulation Of Blood Circulation Regulation Of Hormone Secretion Cell Migration Angiotensin Type I Receptor Activity Response To Iron Ion	Regulation Of Amyloid Precursor Protein Catabolic Process Endoplasmic Reticulum Tubular Network Formation Endoplasmic Reticulum Tubular Network Membrane Organization Endoplasmic Reticulum Membrane Organization Endoplasmic Reticulum Tubular Network Organization Neuron Projection Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Regulation Of Amyloid-beta Formation Endoplasmic Reticulum Organization Regulation Of Amide Metabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Golgi Apparatus Brain Development Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Cellular Response To Norepinephrine Stimulus Endoplasmic Reticulum Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Postsynaptic Density Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Main Axon Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Axon Choice Point Recognition Neuron Differentiation Heparan Sulfate Binding