CDKN2C and ATR

Number of citations of the paper that reports this interaction (PMID 15680327)
26

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CDKN2C	ATR
Gene Name		cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	ATR serine/threonine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	XY Body Nucleoplasm Chromosome Golgi Apparatus PML Body
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MutLalpha Complex Binding MutSalpha Complex Binding Protein Dimerization Activity
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Oligodendrocyte Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity	DNA Damage Checkpoint Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Cell Cycle Multicellular Organismal Development Negative Regulation Of DNA Replication Peptidyl-serine Phosphorylation Cellular Response To Heat Cellular Response To UV Response To Drug Regulation Of Protein Binding Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Autophosphorylation Cellular Response To Gamma Radiation Replicative Senescence Regulation Of Cellular Response To Heat
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	Fanconi Anemia pathway G2/M DNA damage checkpoint G2/M Checkpoints Meiotic synapsis Regulation of HSF1-mediated heat shock response Cellular response to heat stress Regulation of the Fanconi anemia pathway Activation of ATR in response to replication stress Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		27 interactors: AHCYL1 APLP1 ATM ATR CCDC90B CDK4 CDK6 CDKN2A COPS6 DRAP1 GDF9 GOPC LRIF1 LY96 MAPK10 MAPK8 NAGK NHP2L1 NIF3L1 PPP2CA RBM48 REL TCF12 TCF4 TLE1 TP53 UNC119	47 interactors: AATF ABL1 AP1B1 AP2A2 ARHGEF1 ATM ATRIP BLM BRCA1 BRCA2 CDKN2C CEP164 CHD4 CHEK1 CHEK2 CLSPN CREB1 DCLRE1C DTL E2F1 E4F1 EEF1E1 EP300 FANCA FANCD2 FLT1 H2AFX KDR LIG4 MCM2 MRE11A MSH2 NBN PA2G4 PIK3CA POLD1 POLN PPP2R2A PTS RAD17 RHEB TP53 TREX1 UPF1 VPRBP XPA XRCC5
Entrez ID		1031	545
HPRD ID		04534	08369
Ensembl ID		ENSG00000123080	ENSG00000175054
Uniprot IDs		P42773 Q6ICV4	Q13535
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?		Replicative Senescence Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Cycle Arrest Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Cell Aging Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process RNA Metabolic Process Cell Cycle Negative Regulation Of Growth Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Signal Transduction Mitotic Cell Cycle JUN Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Cell Aging Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Signaling Negative Regulation Of Cell Growth Response To Gamma Radiation Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Response To Light Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Apoptotic Process Cell Communication Positive Regulation Of Programmed Cell Death Cellular Metabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Death	Cellular Response To DNA Damage Stimulus DNA Repair DNA Metabolic Process Cellular Response To Stress Cell Cycle Process Cell Cycle DNA Damage Checkpoint Double-strand Break Repair DNA Replication Cell Cycle Checkpoint DNA Recombination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Response To Stress Regulation Of Cell Cycle Response To Ionizing Radiation Mitotic Cell Cycle Nitrogen Compound Metabolic Process Response To Radiation Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Regulation Of Mitotic Cell Cycle G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cellular Response To Stimulus Intrinsic Apoptotic Signaling Pathway Chromosome Organization Negative Regulation Of Mitotic Cell Cycle Response To Abiotic Stimulus Apoptotic Signaling Pathway Double-strand Break Repair Via Homologous Recombination Recombinational Repair Organelle Organization Response To Stimulus Cell Cycle Arrest Negative Regulation Of DNA Metabolic Process Response To X-ray Mitotic DNA Integrity Checkpoint Mitotic Cell Cycle Checkpoint Signal Transduction By P53 Class Mediator Telomere Maintenance Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Macromolecule Biosynthetic Process Negative Regulation Of DNA Replication B Cell Activation Signal Transduction In Response To DNA Damage Biosynthetic Process
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed	activators breakage broad chromatin chromosome comprises concept defect discuss emerging exert heterochromatin hybrid inherited mediate member modulating mr numerous observations remodelling repair retardation seems segregation snf2 somehow thalaessemia xnp
Tagcloud (Intersection) ?