CDKN2C and CCDC90B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDKN2C	CCDC90B
Gene Name		cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	coiled-coil domain containing 90B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Integral Component Of Membrane
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Oligodendrocyte Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		27 interactors: AHCYL1 APLP1 ATM ATR CCDC90B CDK4 CDK6 CDKN2A COPS6 DRAP1 GDF9 GOPC LRIF1 LY96 MAPK10 MAPK8 NAGK NHP2L1 NIF3L1 PPP2CA RBM48 REL TCF12 TCF4 TLE1 TP53 UNC119	29 interactors: AGR2 ANXA7 ARL15 BTBD2 CDKN2B CDKN2C DLEU1 DNM2 EIF2S2 FXYD6 KDM1A LAMTOR1 NACA NIPSNAP3A PAFAH1B3 PCDHA4 PIN1 PNP PRDX5 PSMD11 RGL2 RNF10 SAT1 SDHAF2 SERPINB9 SMN1 TAC3 TK1 TSC22D1
Entrez ID		1031	60492
HPRD ID		04534	14378
Ensembl ID		ENSG00000123080	ENSG00000137500
Uniprot IDs		P42773 Q6ICV4	B3KP87 Q9GZT6
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?		Replicative Senescence Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Cycle Arrest Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Cell Aging Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process RNA Metabolic Process Cell Cycle Negative Regulation Of Growth Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Signal Transduction Mitotic Cell Cycle JUN Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Cell Aging Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Signaling Negative Regulation Of Cell Growth Response To Gamma Radiation Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Response To Light Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Apoptotic Process Cell Communication Positive Regulation Of Programmed Cell Death Cellular Metabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Death	Regulation Of Cell Proliferation Developmental Process System Development Anatomical Structure Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Nucleoside Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Multicellular Organismal Development Reactive Nitrogen Species Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Inosine Catabolic Process Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Primitive Erythrocyte Differentiation Nicotinamide Riboside Catabolic Process Fetal Process Involved In Parturition Mitochondrial Electron Transport, Succinate To Ubiquinone NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Membrane Tubulation Mucus Secretion Spermidine Acetylation Skeletal Muscle Cell Proliferation Interleukin-2 Secretion Urate Biosynthetic Process Purine Nucleoside Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Oxidoreductase Activity Endosome Localization Lung Goblet Cell Differentiation Protein-FAD Linkage Regulation Of Cholesterol Import Putrescine Catabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Response To Stimulus
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?