CDKN2C and NHP2L1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		CDKN2C	NHP2L1
Gene Name		cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Spliceosomal Complex Nucleolus Box C/D SnoRNP Complex Protein Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	RNA Binding Protein Binding SnoRNA Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Oligodendrocyte Differentiation Negative Regulation Of Protein Serine/threonine Kinase Activity	MRNA Splicing, Via Spliceosome RNA Splicing Gene Expression Ribosome Biogenesis
Pathways		Cyclin D associated events in G1 Oxidative Stress Induced Senescence G1 Phase Cellular Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Mitotic G1-G1/S phases Cell Cycle, Mitotic	Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Minor Pathway mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Ventricular conduction ( 21076409)
Protein-Protein Interactions		27 interactors: AHCYL1 APLP1 ATM ATR CCDC90B CDK4 CDK6 CDKN2A COPS6 DRAP1 GDF9 GOPC LRIF1 LY96 MAPK10 MAPK8 NAGK NHP2L1 NIF3L1 PPP2CA RBM48 REL TCF12 TCF4 TLE1 TP53 UNC119	14 interactors: CDKN2C CHST1 GTF3C1 LRIF1 MAP1LC3B POLA2 PPIH PRPF3 PRPF31 PRPF4 RAD17 RBM10 SNW1 XRCC6
Entrez ID		1031	4809
HPRD ID		04534	03197
Ensembl ID		ENSG00000123080	ENSG00000100138
Uniprot IDs		P42773 Q6ICV4	P55769 Q6FHM6
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6	1E7K 2JNB 2OZB 3SIU 3SIV
Enriched GO Terms of Interacting Partners?		Replicative Senescence Regulation Of Gene Expression Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Signal Transduction Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Cycle Arrest Regulation Of Nitrogen Compound Metabolic Process Cell Cycle Process Cell Aging Positive Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Process RNA Metabolic Process Cell Cycle Negative Regulation Of Growth Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Regulation Of Signal Transduction Signal Transduction Mitotic Cell Cycle JUN Phosphorylation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Positive Regulation Of Cell Aging Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Signaling Negative Regulation Of Cell Growth Response To Gamma Radiation Regulation Of Signaling Positive Regulation Of Cellular Metabolic Process Response To Light Stimulus Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Apoptotic Process Cell Communication Positive Regulation Of Programmed Cell Death Cellular Metabolic Process Cellular Response To Ionizing Radiation Positive Regulation Of Cell Death	RNA Splicing MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process RNA Processing Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Spliceosomal Tri-snRNP Complex Assembly RNA Metabolic Process Gene Expression Cellular Metabolic Process Spliceosomal SnRNP Assembly Positive Regulation Of Viral Process Telomere Maintenance Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Hyperosmotic Salinity Response Macromolecule Biosynthetic Process 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter TRNA Transcription From RNA Polymerase III Promoter Cellular Response To X-ray Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of Viral Process G1/S Transition Of Mitotic Cell Cycle TRNA Transcription Ribonucleoprotein Complex Assembly Establishment Of Integrated Proviral Latency Metabolic Process Cellular Hyperosmotic Response Hyperosmotic Salinity Response Establishment Of Viral Latency Positive Regulation By Host Of Viral Transcription Mitotic Cell Cycle Process DNA Replication Checkpoint Cellular Response To Salt Stress DNA Recombination Mitotic Cell Cycle DNA Ligation
Tagcloud ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Difference) ?		a134c abp allelic ankyrin balb cdk6 cdnas chr congenic d2 dba g232a ifna inbred inefficient ink4c le multigenic mus p15 p16 p18 pctr1 plasmacytoma pristane spretus typed
Tagcloud (Intersection) ?