CDKN2C and STK11

Number of citations of the paper that reports this interaction (PubMedID 28205554)
55

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDKN2C	STK11
Description		cyclin dependent kinase inhibitor 2C	serine/threonine kinase 11
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Mitochondrion Centrosome Cytosol Cilium Membrane Extracellular Exosome Intracellular Protein-containing Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Nucleotide Binding Magnesium Ion Binding P53 Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity LRR Domain Binding Protein Kinase Activator Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Oligodendrocyte Differentiation Stem Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Proliferation	Regulation Of Cell Growth Tissue Homeostasis Vasculature Development Protein Phosphorylation Protein Dephosphorylation Autophagy Apoptotic Process DNA Damage Response Signal Transduction Spermatogenesis Axonogenesis Negative Regulation Of Cell Population Proliferation Response To Ionizing Radiation Positive Regulation Of Autophagy Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Activation Of Protein Kinase Activity Protein Localization To Nucleus Glucose Homeostasis Anoikis Positive Thymic T Cell Selection Protein Autophosphorylation Regulation Of Dendrite Morphogenesis Positive Regulation Of Axonogenesis T Cell Receptor Signaling Pathway Golgi Localization Regulation Of Cell Cycle Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development G1 To G0 Transition Cellular Response To UV-B Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Canonical Wnt Signaling Pathway Dendrite Extension Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Vesicle Transport Along Microtubule Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of TORC1 Signaling
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes
Drugs
Diseases			Peutz-Jeghers syndrome Pancreatic cancer
GWAS		Atrial fibrillation ( 29290336) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 33713608 31562340) Hip circumference adjusted for BMI ( 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)	Asthma (childhood onset) ( 31036433) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Distal/Left-sided colorectal cancer ( 33632709) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) PR interval ( 32439900) Psychosis in Alzheimer's disease ( 22005930)
Interacting Genes		59 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 CRX CTDSP1 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 KRT31 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PBX4 PDGFRA PLEKHG4 POU6F2 PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 SORBS3 ST14 STK11 TCF12 TCF4 TLE1 TP53 UBC UNC119	133 interacting genes: ABCB5 ADIPOR1 AKT1 ALDOB ANP32B APP ARAF ARG2 ARNT ATM AURKA BAP1 BCAS3 BECN1 BRAF CAB39 CALM2 CBLC CCDC180 CCND2 CCNE1 CD44 CDC14B CDC37 CDK4 CDK6 CDKN2A CDKN2B CDKN2C CFL2 CRY2 CTSB CYLC2 CYP17A1 D2HGDH DACH1 EEF1A2 EPHA2 ERBB2 ERLEC1 ETV4 FAIM2 FBP1 FBP2 FGFR4 FZR1 GLIS2 GNPDA1 GRM1 HERC2 HGF HIF1A HRAS IGFBP3 KAT2A KDELR2 KLK7 LATS2 LEF1 LYPD3 MAP2K1 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MAPK14 MAPK3 MAPRE1 MARK1 MARK2 MARK4 MET MOB4 MOCS2 MT-ND2 MYC NANS NAT2 NF2 PARD3 PDGFRA PDXP PHF23 PIK3CA PLD3 PPP2CB PRKAA2 PRKACA PRSS50 PTEN RASA1 RASSF1 RHOBTB2 RPS6KA3 RPS6KA5 RPS6KB1 S100A14 SEPTIN9 SIK1 SIRT1 SKP2 SMAD1 SMARCA4 SNRK SOX4 SPDEF ST14 STK11IP STK24 STRADA STRADB STX17 TBC1D23 TDRD7 TEAD2 TERT THOP1 THRSP TNFRSF1A TNIP2 TP53 TRIM25 TRMO TSG101 TUBA1A TUBB4A UBE2D2 VPS72 WT1 XPA YWHAG ZNF189 ZNF510
Entrez ID		1031	6794
HPRD ID		04534	03740
Ensembl ID		ENSG00000123080	ENSG00000118046
Uniprot IDs		P42773 Q6ICV4	A0A0S2Z4D1 Q15831
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6	2WTK 4ZDR 5WXN 8VSU
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle Phase Transition Cellular Senescence Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Protein Phosphorylation Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Signal Transduction MAPK Cascade Regulation Of Cell Cycle Process Replicative Senescence Positive Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Metabolic Process Response To Radiation Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Response To UV Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Light Stimulus Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication ATP Binding Regulation Of Catalytic Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition	Protein Kinase Activity Intracellular Signal Transduction Protein Serine Kinase Activity Kinase Activity Regulation Of Programmed Cell Death Protein Serine/threonine Kinase Activity Regulation Of Apoptotic Process Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Protein Phosphorylation Regulation Of Signal Transduction Cytoplasm Phosphorylation Regulation Of Phosphorus Metabolic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Nucleotide Binding Signal Transduction Regulation Of Cell Population Proliferation Cellular Senescence Apoptotic Process Protein Modification Process Transferase Activity Programmed Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Death Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Cycle Process Intracellular Signaling Cassette Regulation Of Metabolic Process Developmental Process Protein Metabolic Process ATP Binding Regulation Of Protein Modification Process Regulation Of Macromolecule Metabolic Process MAPK Cascade Negative Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Differentiation Cellular Developmental Process Regulation Of Primary Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Macromolecule Metabolic Process
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