CDKN2C and PPP2CA

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CDKN2C	PPP2CA
Description		cyclin dependent kinase inhibitor 2C	protein phosphatase 2 catalytic subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Chromatin Spindle Pole Nucleus Chromosome Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Protein Serine/threonine Phosphatase Complex Microtubule Cytoskeleton Membrane Membrane Raft Synapse Extracellular Exosome FAR/SIN/STRIPAK Complex INTAC Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Metal Ion Binding Protein Heterodimerization Activity Tau Protein Binding GABA Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
	Biological Process	Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Oligodendrocyte Differentiation Stem Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Stem Cell Proliferation	Mitotic Cell Cycle Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Protein Dephosphorylation Mesoderm Development Response To Lead Ion Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Microtubule Polymerization Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-threonine Dephosphorylation Regulation Of Growth T Cell Homeostasis Regulation Of Cell Differentiation Meiotic Cell Cycle Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Canonical Wnt Signaling Pathway Vascular Endothelial Cell Response To Oscillatory Fluid Shear Stress RNA Polymerase II Transcription Initiation Surveillance Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1	Inhibition of replication initiation of damaged DNA by RB1/E2F1 Spry regulation of FGF signaling Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PP2A-mediated dephosphorylation of key metabolic factors DARPP-32 events Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade ERK/MAPK targets ERKs are inactivated MASTL Facilitates Mitotic Progression Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Initiation of Nuclear Envelope (NE) Reformation Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Regulation of glycolysis by fructose 2,6-bisphosphate metabolism EML4 and NUDC in mitotic spindle formation Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PKR-mediated signaling Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs			Vitamin E 2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS		Atrial fibrillation ( 29290336) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 33713608 31562340) Hip circumference adjusted for BMI ( 34021172) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Thyroid stimulating hormone levels ( 32769997) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		59 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 CRX CTDSP1 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 KRT31 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PBX4 PDGFRA PLEKHG4 POU6F2 PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 SORBS3 ST14 STK11 TCF12 TCF4 TLE1 TP53 UBC UNC119	101 interacting genes: ADCY8 AKAP6 AKT1 AKT3 AMOTL2 APC AXIN1 BCL2 BEST1 BMPR1B BRAF C3orf36 CAD CAMK1 CARD11 CAV1 CCNG1 CCNG2 CDC42BPB CDK2 CDK6 CDKN2C CEBPA CHEK2 CLPP CSNK2B CXCR2 DELEC1 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 KISS1R L3MBTL3 MAP4K1 MAP4K3 MAP4K4 MAPK1 MAPK3 MAPT MID1 MRPS26 MYC MYH9 NME2 NOSIP NXN PACS1 PAK1 PIM1 POLR2A PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTEN PTN PXN PYGM RACGAP1 RBL2 RELA RHO RHOB RORC RPS6KB1 RRAS SET SGK1 SGO1 SGO2 STAT5A STAT5B STRN TIAM1 TLX1 TP53 TRIM28 TRIM35 TRIP13 TSC2 UBAP2 UBC VAC14 VDR XRN1 YPEL3
Entrez ID		1031	5515
HPRD ID		04534	08912
Ensembl ID		ENSG00000123080	ENSG00000113575
Uniprot IDs		P42773 Q6ICV4	B3KQ51 B3KUN1 P67775
PDB IDs		1BU9 1G3N 1IHB 1MX2 1MX4 1MX6	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP 4LAC 4NY3 5W0W 6NTS 7CUN 7K36 7PKS 7SOY 7YCX 8RBX 8RBZ 8RC4 8SO0 8TTB 8TWE 8TWI 8U1X 8U89 8UWB 8YJB
Enriched GO Terms of Interacting Partners?		Kinase Activity Protein Kinase Activity Regulation Of Mitotic Cell Cycle Phase Transition Protein Serine Kinase Activity Regulation Of Cell Cycle Phase Transition Cellular Senescence Phosphorylation Protein Serine/threonine Kinase Activity Regulation Of Mitotic Cell Cycle Protein Phosphorylation Intracellular Signal Transduction Mitotic Cell Cycle Phase Transition Regulation Of Primary Metabolic Process Regulation Of Epithelial Cell Proliferation Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Signal Transduction MAPK Cascade Regulation Of Cell Cycle Process Replicative Senescence Positive Regulation Of Signal Transduction Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Metabolic Process Response To Radiation Regulation Of Cell Population Proliferation G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Regulation Of RNA Metabolic Process Regulation Of Signal Transduction Intracellular Signaling Cassette Positive Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Positive Regulation Of Cell Communication Response To UV Positive Regulation Of Signaling Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Light Stimulus Cellular Response To Radiation Regulation Of Signaling Regulation Of Cell Communication ATP Binding Regulation Of Catalytic Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphorus Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition	Signal Transduction Intracellular Signal Transduction Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Cytosol Regulation Of Cell Population Proliferation Protein Phosphatase Regulator Activity Protein Phosphorylation Protein Phosphatase Type 2A Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Kinase Activity Phosphorylation Regulation Of Protein Metabolic Process Intracellular Signaling Cassette Apoptotic Process Regulation Of Cell Cycle Programmed Cell Death Cell Death Protein Phosphatase 2A Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signal Transduction Cytoplasm Nucleus Response To Ketone Response To Lipid Regulation Of Mitotic Cell Cycle Response To Starvation Positive Regulation Of Intracellular Signal Transduction Protein Modification Process Regulation Of Cell Differentiation Positive Regulation Of Cell Population Proliferation Identical Protein Binding Positive Regulation Of Apoptotic Process Cellular Response To Stress Protein Metabolic Process Response To Nutrient Levels Positive Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Component Organization Cellular Response To Oxygen-containing Compound
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