CNKSR1 and PTPN6

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		CNKSR1	PTPN6
Description		connector enhancer of kinase suppressor of Ras 1	protein tyrosine phosphatase non-receptor type 6
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Extracellular Region Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Protein-containing Complex Specific Granule Lumen Alpha-beta T Cell Receptor Complex Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Phosphotyrosine Residue Binding Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Non-membrane Spanning Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity SH3 Domain Binding Protein Kinase Binding SH2 Domain Binding Cell Adhesion Molecule Binding Phosphorylation-dependent Protein Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	MAPK Cascade Mitotic Cell Cycle Pattern Recognition Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Neutrophil Activation Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Protein Dephosphorylation G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Platelet Formation T Cell Costimulation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Intracellular Signal Transduction Megakaryocyte Development T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Natural Killer Cell Mediated Cytotoxicity Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Regulation Of B Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Negative Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Inflammatory Response To Wounding Negative Regulation Of Inflammatory Response To Wounding CD27 Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neutrophil Activation Epididymis Development Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	GPVI-mediated activation cascade Regulation of KIT signaling Signaling by ALK PECAM1 interactions Co-inhibition by PD-1 Signal regulatory protein family interactions Platelet sensitization by LDL Interleukin-3, Interleukin-5 and GM-CSF signaling CD22 mediated BCR regulation Neutrophil degranulation Interferon gamma signaling Regulation of IFNG signaling Interleukin-37 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA/IFNB signaling SARS-CoV-2 activates/modulates innate and adaptive immune responses Nuclear events stimulated by ALK signaling in cancer Growth hormone receptor signaling Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Co-inhibition by BTLA
Drugs			Tiludronic acid
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Mean corpuscular hemoglobin concentration ( 29403010) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	118 interacting genes: AATK ABL1 ACTN1 ACTN4 BCR BLNK BTLA CAV1 CBL CCDC88A CD22 CD247 CD300LF CD33 CD5 CD72 CD79A CD79B CDK1 CEACAM1 CLEC4A CNKSR1 CSF2RB CTNNB1 CTNND1 CUZD1 CXCR4 DOK1 EGFR EPOR ERBB2 ERBB3 ERBB4 ESR1 FAS FCGR2B FCRL3 FGFR4 FHL3 FLT3 GAB2 GHR GRB2 H2BC3 HOXA10 IFNAR1 IGF1R IL2RB IL4R IL6ST INSR IRS2 IRS4 JAK1 JAK2 JAK3 KDR KHDRBS1 KIR2DL3 KIR2DL5A KIT KLRA1P KLRB1 KLRC1 LAIR1 LAT LCK LCP2 LIFR LILRB2 LILRB4 LMTK2 LYN MPIG6B MS4A2 MYH9 NOS1 OLIG1 PAG1 PDGFRB PECAM1 PIK3R1 PILRA PILRB PLCG2 PRKCA PRKCD PTK2B PTK7 PTPN11 PTPRC ROR1 ROR2 ROS1 SHC1 SIGLEC10 SIGLEC11 SIGLEC12 SIRPA SLAMF6 SNCA SOS1 SPATA2 SRC SSTR2 STAT5B STAT6 SYK TFG TLR10 TMEM62 TNFRSF1A TRAF3 TRAF6 TREML1 TYK2 VAV1 ZAP70
Entrez ID		10256	5777
HPRD ID		11937	01475
Ensembl ID		ENSG00000142675	ENSG00000111679
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	P29350 Q53XS4
PDB IDs		1WWV	1FPR 1GWZ 1X6C 2B3O 2RMX 2YU7 3PS5 4GRY 4GRZ 4GS0 4HJP 4HJQ 6SM5 8YHI
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Cell Surface Receptor Signaling Pathway Signal Transduction Plasma Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Regulation Of Immune Response Regulation Of Immune System Process Enzyme-linked Receptor Protein Signaling Pathway Immune System Process Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Immune Response-regulating Signaling Pathway Leukocyte Activation Cell Activation Regulation Of MAPK Cascade Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune System Process Regulation Of Lymphocyte Activation Membrane Lymphocyte Activation Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Protein Kinase Activity Regulation Of Signal Transduction Regulation Of T Cell Activation Regulation Of Intracellular Signal Transduction Immune Response Positive Regulation Of Intracellular Signal Transduction Adaptive Immune Response Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Protein Phosphatase Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response Regulation Of Multicellular Organismal Process Protein Phosphorylation Regulation Of Leukocyte Proliferation External Side Of Plasma Membrane Fc Receptor Signaling Pathway Kinase Activity Immune Response-activating Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Regulation Of Cell Population Proliferation B Cell Activation Mononuclear Cell Differentiation
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