CNKSR1 and DUSP7

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		CNKSR1	DUSP7
Description		connector enhancer of kinase suppressor of Ras 1	dual specificity phosphatase 7
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/threonine Phosphatase Activity Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine Phosphatase Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	MAPK Cascade Signal Transduction Peptidyl-tyrosine Dephosphorylation Negative Regulation Of MAP Kinase Activity Negative Regulation Of MAPK Cascade ERK1 And ERK2 Cascade Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	RAF-independent MAPK1/3 activation ERKs are inactivated Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	10 interacting genes: CFTR CNKSR1 EEF1A1 EGLN3 GHR IL16 MAPK1 MAPK14 MAPK8 SPOP
Entrez ID		10256	1849
HPRD ID		11937	04125
Ensembl ID		ENSG00000142675	ENSG00000164086
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q16829
PDB IDs		1WWV	4Y2E
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	MAP Kinase Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Cytokine-mediated Signaling Pathway Protein Phosphatase Binding Response To Lipid Regulation Of Ossification Positive Regulation Of Neuroinflammatory Response Locomotion Positive Regulation Of Chemotaxis Cell Surface Receptor Signaling Pathway Chemotaxis Ficolin-1-rich Granule Lumen Positive Regulation Of Cyclase Activity Peptidyl-threonine Phosphorylation Regulation Of Inflammatory Response Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Inflammatory Response Response To Nutrient Levels Insulin-like Growth Factor Receptor Signaling Pathway Canonical Inflammasome Complex Assembly Regulation Of Chemotaxis Response To Cytokine Regulation Of Neuroinflammatory Response Lipopolysaccharide-mediated Signaling Pathway Response To Peptide Positive Regulation Of Interleukin-12 Production MAPK Cascade Positive Regulation Of Locomotion Response To Epidermal Growth Factor Enzyme-linked Receptor Protein Signaling Pathway Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding JUN Phosphorylation Homeostatic Process Protein Metabolic Process Cellular Senescence Regulation Of Interleukin-12 Production Cellular Response To Amino Acid Starvation Response To Amino Acid Starvation Response To Lipopolysaccharide Cytoplasm Positive Regulation Of Establishment Of Protein Localization Response To Growth Factor Energy Homeostasis Positive Regulation Of Anion Channel Activity Regulation Of Cytokine Production Involved In Inflammatory Response Chemokine-mediated Signaling Pathway Chemokine (C-C Motif) Ligand 5 Binding
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