CNKSR1 and ILKAP

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		CNKSR1	ILKAP
Description		connector enhancer of kinase suppressor of Ras 1	ILK associated serine/threonine phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Cytoplasm
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Hydrolase Activity Cation Binding Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Signal Transduction
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Phospholipid levels (plasma) ( 22359512) Red cell distribution width ( 27863252)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	24 interacting genes: AATK CHEK1 CNKSR1 EGFR EPHA2 EPHA3 ERBB2 ERBB3 ERBB4 FBXO7 HGS IGF1R ILK KDR KIT LMTK2 MAPK14 MUSK OGT PTK7 ROR1 ROR2 RPS6KA3 TEK
Entrez ID		10256	80895
HPRD ID		11937	17147
Ensembl ID		ENSG00000142675	ENSG00000132323
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q9H0C8
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Protein Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Kinase Activity ATP Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Nucleotide Binding Transferase Activity Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction Growth Factor Binding Regulation Of Developmental Process Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Protein Phosphorylation Coreceptor Activity ERBB2 Signaling Pathway Basal Plasma Membrane Phosphorylation Regulation Of Locomotion Regulation Of Cellular Component Organization Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Negative Regulation Of Programmed Cell Death Positive Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial Cell Proliferation Cell Population Proliferation Regulation Of Cell Migration Positive Regulation Of Signal Transduction Regulation Of Cell Motility Regulation Of Cell Population Proliferation Positive Regulation Of Cell Migration Cellular Developmental Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Protein Autophosphorylation Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Animal Organ Development Positive Regulation Of Phosphorylation
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