CNKSR1 and BRAP

Number of citations of the paper that reports this interaction (PMID 14724641)
52

Data Source:
HPRD (in vivo)

		CNKSR1	BRAP
Gene Name		connector enhancer of kinase suppressor of Ras 1	BRCA1 associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Ubiquitin Ligase Complex Cytoplasm Nuclear Membrane
	Molecular Function	Protein Binding, Bridging	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ligase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	MAPK Cascade Ras Protein Signal Transduction Negative Regulation Of Signal Transduction Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS			Cholesterol, total ( 20686565) Drinking behavior ( 21372407) Esophageal cancer ( 19698717) Hematological and biochemical traits ( 20139978) Hypothyroidism ( 22493691) LDL cholesterol ( 20686565)
Protein-Protein Interactions		18 interactors: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SMAD4 STK3 STK4 ZDHHC17	15 interactors: BRCA1 CDC14A CENPF CNKSR1 DDB1 HMG20A HRAS NUMA1 SYNE2 TRIM41 TRIM55 TRIM8 UBE2H USP15 USP4
Entrez ID		10256	8315
HPRD ID		11937	05405
Ensembl ID		ENSG00000142675	ENSG00000089234
Uniprot IDs		Q53GM7 Q969H4	Q59H81 Q7Z569
PDB IDs		1WWV
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Signaling Endocardium Development Small GTPase Mediated Signal Transduction Cell Communication Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Protein Autophosphorylation Primitive Hemopoiesis Response To Stimulus Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process	Protein Ubiquitination Protein Modification By Small Protein Conjugation Regulation Of Viral Release From Host Cell Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Organelle Organization Cellular Protein Modification Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cell Cycle Checkpoint Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Establishment Of Organelle Localization Negative Regulation Of Gene Expression Cell Cycle Positive Regulation Of Histone H3-K9 Acetylation Histone H2B Conserved C-terminal Lysine Deubiquitination Negative Regulation Of Chromosome Organization Cellular Macromolecule Catabolic Process Regulation Of Protein Catabolic Process Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Positive Regulation By Virus Of Viral Protein Levels In Host Cell Organelle Localization Regulation Of Mitotic Cell Cycle Protein Deubiquitination Regulation Of Cell Cycle Cell Division Cellular Protein Metabolic Process Nuclear Migration Along Microfilament G2/M Transition Of Mitotic Cell Cycle Protein Modification By Small Protein Removal Response To Radiation Negative Regulation Of Cell Cycle Nucleus Organization Chromosome Organization Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Indole-3-methanol Cell Cycle Process Regulation Of Cell Cycle Process Cellular Metabolic Process Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Centriole Replication Positive Regulation Of DNA Metabolic Process Cytoskeleton Organization Regulation Of Viral Process
Tagcloud ?			centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold
Tagcloud (Difference) ?			centers cns complexity epistasis extraordinary fail fashion fate geographical graded gradients hyperactivation individualized ksr lis1 makes mapk midline mitogenic modulator nde1 overlapping overproliferation precision renew scaffold spatially spatiotemporally threshold
Tagcloud (Intersection) ?