CNKSR1 and PPP1R8

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down)

		CNKSR1	PPP1R8
Description		connector enhancer of kinase suppressor of Ras 1	protein phosphatase 1 regulatory subunit 8
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Nuclear Speck
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	DNA Binding RNA Binding MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Phosphatase Inhibitor Activity Protein Serine/threonine Phosphatase Inhibitor Activity Protein Binding Ribonuclease E Activity Hydrolase Activity Protein Phosphatase Regulator Activity Molecular Function Inhibitor Activity
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	MRNA Processing RNA Catabolic Process Cell Population Proliferation RNA Splicing
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	28 interacting genes: APP APPBP2 CDC5L CNKSR1 CREBBP CRMP1 CSNK2A1 CSNK2A2 CTNNBL1 EED ERG28 FBXO25 GBP2 HDAC2 HMGA1 LRRK2 LYN MELK PPIL1 PPP1CA PPP1CC PRKACA RBM48 RTN4IP1 SETDB1 SF3B1 STC2 WDR77
Entrez ID		10256	5511
HPRD ID		11937	04028
Ensembl ID		ENSG00000142675	ENSG00000117751
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q12972 Q6ICT4
PDB IDs		1WWV	3V4Y
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Macromolecule Metabolic Process Nucleoplasm Postsynapse Cellular Response To Catecholamine Stimulus Response To Catecholamine Protein Modification Process Protein Kinase CK2 Complex Intracellular Signal Transduction Protein Metabolic Process Spliceosomal Complex Cellular Response To Stress Regulation Of Proteolysis Enzyme Binding MRNA Metabolic Process Rhythmic Process Cellular Response To Dopamine PTW/PP1 Phosphatase Complex Chromatin Remodeling Negative Regulation Of Macromolecule Metabolic Process Signaling Receptor Activator Activity Nucleobase-containing Compound Metabolic Process MRNA Processing Response To Dopamine Cellular Response To Heat Perikaryon Cellular Response To Manganese Ion Chromatin Binding Protein Kinase Activity DNA Repair Positive Regulation Of Gliogenesis Regulation Of Carbohydrate Catabolic Process Negative Regulation Of Metabolic Process Nucleic Acid Metabolic Process Circadian Regulation Of Gene Expression DNA Damage Response Positive Regulation Of Programmed Cell Death Nucleus Response To Manganese Ion Prp19 Complex Protein Serine Kinase Activity Golgi-associated Vesicle Chromatin Organization Regulation Of Apoptotic Process Regulation Of Protein Catabolic Process RNA Splicing MRNA Splicing, Via Spliceosome Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macroautophagy ESC/E(Z) Complex Negative Regulation Of Gene Expression
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