CNKSR1 and PTPRH

Number of citations of the paper that reports this interaction (PubMedID 34187934)
69

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		CNKSR1	PTPRH
Description		connector enhancer of kinase suppressor of Ras 1	protein tyrosine phosphatase receptor type H
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell-cell Junction Cell Cortex Membrane	Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Nuclear Speck Microvillus Membrane Cell Projection
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway	Protein Dephosphorylation Apoptotic Process Signal Transduction Axon Guidance
Pathways		MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs
Diseases
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum metabolite levels ( 33031748) Systemic lupus erythematosus ( 28714469)
Interacting Genes		37 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 DSCR9 DUSP10 DUSP7 ENPP3 G6PC3 ILKAP MAP2K2 MAP2K7 MAP3K10 PIN1 PPFIA1 PPFIA3 PPP1R14C PPP1R8 PTPN18 PTPN6 PTPRH PTPRJ PTPRM PTPRR RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 TCAF1 ZDHHC17 ZGPAT	16 interacting genes: BCAR1 CNKSR1 CRK DHPS DOK1 EGFR ERBB3 ERBB4 GHR KRTAP10-3 KRTAP10-8 LCK MAPK1 MLH1 PTK2 PXN
Entrez ID		10256	5794
HPRD ID		11937	03942
Ensembl ID		ENSG00000142675	ENSG00000080031
Uniprot IDs		B4DL25 G3V160 Q53GM7 Q969H4	Q9HD43
PDB IDs		1WWV	7XC0
Enriched GO Terms of Interacting Partners?		Regulation Of MAPK Cascade Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity MAPK Cascade Intracellular Signaling Cassette Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Protein Modification Process Dephosphorylation Regulation Of Phosphorus Metabolic Process Protein Dephosphorylation Transmembrane Receptor Protein Tyrosine Phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Serine/threonine Kinase Activity Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Protein Kinase Activity Positive Regulation Of Phosphorylation Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Signal Transduction Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Motility Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Motility Regulation Of Protein Metabolic Process Negative Regulation Of Locomotion Regulation Of Locomotion Regulation Of MAP Kinase Activity Peptidyl-tyrosine Dephosphorylation ERBB2 Signaling Pathway Hydrolase Activity Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Cell Population Proliferation Small GTPase-mediated Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Primitive Hemopoiesis Anatomical Structure Formation Involved In Morphogenesis Negative Regulation Of ERBB Signaling Pathway	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Phosphatase Binding SH2 Domain Binding Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activator Activity Signal Transduction Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Macrophage Proliferation Response To Growth Factor Phosphotyrosine Residue Binding Cell Migration Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Kinase Activity Response To Epidermal Growth Factor B Cell Receptor Signaling Pathway Signal Complex Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Cell Motility Receptor Complex Basal Plasma Membrane Immune Response-regulating Signaling Pathway Focal Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of Phosphorylation Response To Hepatocyte Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Schwann Cell Development Positive Regulation Of Cell Migration T Cell Receptor Signaling Pathway
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