CNKSR1 and STK4

Number of citations of the paper that reports this interaction (PMID 15075335)
23

Data Source:
HPRD (in vivo)

		CNKSR1	STK4
Gene Name		connector enhancer of kinase suppressor of Ras 1	serine/threonine kinase 4
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Cell Cortex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding, Bridging	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Dimerization Activity
	Biological Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction	Cell Morphogenesis Patterning Of Blood Vessels Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Central Nervous System Development Negative Regulation Of Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation Keratinocyte Differentiation Positive Regulation Of Protein Binding Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways			Signaling by Hippo
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SMAD4 STK3 STK4 ZDHHC17	16 interactors: AKT1 CASP3 CNKSR1 CSN1S1 HIST2H2BE IL2RG LATS1 MBP NEDD4 PRKRIR RASSF1 RASSF5 SAV1 SGMS1 SIRT1 TP53
Entrez ID		10256	6789
HPRD ID		11937	05395
Ensembl ID		ENSG00000142675	ENSG00000101109
Uniprot IDs		Q53GM7 Q969H4	Q13043
PDB IDs		1WWV	2JO8 3COM
Enriched GO Terms of Interacting Partners?		Regulation Of Signal Transduction Regulation Of Signaling Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Signal Transduction Positive Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Signaling Endocardium Development Small GTPase Mediated Signal Transduction Cell Communication Neurotrophin TRK Receptor Signaling Pathway Regulation Of Protein Phosphorylation Neurotrophin Signaling Pathway MAPK Cascade Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of MAPK Cascade Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Protein Metabolic Process Regulation Of Stress-activated MAPK Cascade Regulation Of Protein Kinase Activity Activation Of MAPKK Activity Positive Regulation Of MAPK Cascade Regulation Of Kinase Activity Protein Autophosphorylation Primitive Hemopoiesis Response To Stimulus Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Metabolic Process	Response To Cytokine Positive Regulation Of Protein Metabolic Process Hippo Signaling Intracellular Signal Transduction Response To Tumor Necrosis Factor Negative Regulation Of Helicase Activity Response To Stimulus Response To UV Signaling Cell Communication Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cell Aging Intrinsic Apoptotic Signaling Pathway Glial Cell Apoptotic Process Response To Radiation Response To Organic Substance Signal Transduction Cellular Response To Organic Substance Negative Regulation Of Protein Kinase Activity Apoptotic Mitochondrial Changes Cellular Response To Stimulus Response To Stress Negative Regulation Of Kinase Activity Positive Regulation Of Protein Modification Process Regulation Of Cell Cycle Apoptotic Process Regulation Of Cell Proliferation Cellular Response To Cytokine Stimulus Programmed Cell Death Keratinocyte Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Protein Metabolic Process Regulation Of Neuron Death Cell Death Cellular Response To Hypoxia Death Positive Regulation Of Cell Death Cellular Response To Decreased Oxygen Levels Negative Regulation Of Transferase Activity Negative Regulation Of Signal Transduction Regulation Of Autophagy Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Protein Phosphorylation Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Aging Cellular Response To Oxygen Levels Negative Regulation Of Cell Proliferation Response To Light Stimulus Apoptotic Signaling Pathway
Tagcloud ?			abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Difference) ?			abl1 centered coactivator damage elicits hematologic hematological hippo inactivation instability lethal malignancies myeloma notably oncogene ongoing pervasive presenting proapoptotic relevance relocalization restores selectively serine synthetic threonine triggering triggers yap1
Tagcloud (Intersection) ?