RNF41 and MARK2

Number of citations of the paper that reports this interaction (PubMedID 24259665)
66

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RNF41	MARK2
Description		ring finger protein 41	microtubule affinity regulating kinase 2
Image
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Nucleoplasm Cytoplasm Mitochondrion Cytoskeleton Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Cell Projection Microtubule Bundle
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity Protein Kinase Activator Activity Cadherin Binding Metal Ion Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Establishment Of Cell Polarity Cell Differentiation Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Neurofibrillary Tangle Assembly
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs			Fostamatinib
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	31 interacting genes: BAIAP2 CAMK1 CASK CREBBP DVL3 EIF2A FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MTCL1 NEDD4 NEDD4L PAK5 PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 YWHAB YWHAZ
Entrez ID		10193	2011
HPRD ID		11520	02753
Ensembl ID		ENSG00000181852	ENSG00000072518
Uniprot IDs		F8VSB6 Q9H4P4	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs		2FZP 2GWF	3IEC 5EAK 5KZ7 5KZ8 8TXY
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Regulation Of Cell Communication Regulation Of Signaling Protein Serine Kinase Activity Regulation Of Signal Transduction Protein Serine/threonine Kinase Activity Regulation Of Neuron Projection Development Cytoplasm Signal Transduction Protein Phosphorylation Regulation Of Dendrite Morphogenesis Regulation Of Protein Localization Phosphorylation Protein Kinase Activity Regulation Of Cell Projection Organization Protein Modification Process Establishment Or Maintenance Of Cell Polarity Regulation Of Dendrite Development Regulation Of Developmental Process Transferase Activity Kinase Activity Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Plasma Membrane Bounded Cell Projection Organization Phosphoserine Residue Binding Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Positive Regulation Of Cellular Component Organization Positive Regulation Of Cell Communication Intracellular Signal Transduction Positive Regulation Of Signaling Positive Regulation Of Cell Projection Organization Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Autophagy Establishment Of Cell Polarity Regulation Of Anatomical Structure Morphogenesis Negative Regulation Of Sodium Ion Transport TORC2 Signaling Regulation Of Synapse Organization Intracellular Protein Localization Establishment Of Localization In Cell Positive Regulation Of Protein Localization Protein Targeting Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Receptor Catabolic Process Negative Regulation Of Signal Transduction Protein Domain Specific Binding
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