RNF41 and RRM2B

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		RNF41	RRM2B
Description		ring finger protein 41	ribonucleotide reductase regulatory TP53 inducible subunit M2B
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GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ribonucleoside-diphosphate Reductase Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Protein Binding Oxidoreductase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	DNA Synthesis Involved In DNA Repair Kidney Development Renal System Process Mitochondrial DNA Replication DNA Repair DNA Damage Response Response To Oxidative Stress Ribonucleoside Diphosphate Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Deoxyribonucleotide Biosynthetic Process 2'-deoxyribonucleotide Biosynthetic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Amine Positive Regulation Of G0 To G1 Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes
Drugs			Cladribine
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Asthma ( 31619474) Height ( 34054925)	Blood protein levels ( 30072576) Chromosomal aberration frequency (total) ( 31586183) Chronic obstructive pulmonary disease ( 28166215) Mean corpuscular hemoglobin ( 29403010) Mean corpuscular volume ( 29403010) Red blood cell count ( 32888494)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	9 interacting genes: CDKN1A CSNK2A1 MDM2 ORC4 RNF41 RRM1 RRM2 SRPK2 TP53
Entrez ID		10193	50484
HPRD ID		11520	05276
Ensembl ID		ENSG00000181852	ENSG00000048392
Uniprot IDs		F8VSB6 Q9H4P4	Q7LG56
PDB IDs		2FZP 2GWF	2VUX 3HF1 4DJN
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G1/S Phase Transition Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Cellular Response To Gamma Radiation Disordered Domain Specific Binding Regulation Of Cell Cycle Process Response To Ionizing Radiation Signal Transduction In Response To DNA Damage Cellular Response To Actinomycin D Ribonucleoside-diphosphate Reductase Complex Ribonucleoside-diphosphate Reductase Activity, Thioredoxin Disulfide As Acceptor Response To Actinomycin D DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Response To Gamma Radiation Regulation Of Mitotic Cell Cycle Cellular Response To UV-C Positive Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Reactive Oxygen Species Metabolic Process Stress-induced Premature Senescence Cellular Response To Ionizing Radiation Cellular Response To UV Cellular Response To Antibiotic Protein-containing Complex Assembly Protein Tetramerization Signal Transduction By P53 Class Mediator DNA Damage Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Negative Regulation Of Mitophagy Cellular Response To Light Stimulus Protein-containing Complex Organization DNA Damage Response Response To UV-C Replicative Senescence Positive Regulation Of Cell Cycle Phase Transition 2'-deoxyribonucleotide Biosynthetic Process Deoxyribonucleotide Biosynthetic Process Protein Heterotetramerization Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of Cell Cycle G2/M Phase Transition Cytosol Regulation Of Signal Transduction By P53 Class Mediator Cellular Component Assembly Mitotic G1/S Transition Checkpoint Signaling Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of DNA Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process
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