RNF41 and GDF11

		RNF41	GDF11
Description		ring finger protein 41	growth differentiation factor 11
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GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Extracellular Region Extracellular Space Protein-containing Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Skeletal System Development Metanephros Development Ureteric Bud Development Transforming Growth Factor Beta Receptor Signaling Pathway Nervous System Development Mesoderm Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Anterior/posterior Pattern Specification Spinal Cord Anterior/posterior Patterning Neuron Differentiation Pancreas Development Activin Receptor Signaling Pathway Amacrine Cell Differentiation Negative Regulation Of Neuron Differentiation Camera-type Eye Morphogenesis Roof Of Mouth Development Positive Regulation Of SMAD Protein Signal Transduction Type B Pancreatic Cell Maturation Negative Regulation Of Amacrine Cell Differentiation
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Refractive error ( 32231278)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	1 interacting genes: ACVR2B
Entrez ID		10193	10220
HPRD ID		11520	04895
Ensembl ID		ENSG00000181852	ENSG00000135414
Uniprot IDs		F8VSB6 Q9H4P4	O95390
PDB IDs		2FZP 2GWF	5E4G 5JHW 5UHM 6MAC 7MRZ
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Venous Blood Vessel Development Activin Receptor Complex Activin Receptor Activity, Type II Activin Receptor Activity Trophoblast Cell Migration Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Embryonic Foregut Morphogenesis Activin Binding Negative Regulation Of Adipose Tissue Development Negative Regulation Of Mitophagy Kinase Activator Activity Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Gastrulation With Mouth Forming Second Regulation Of Adipose Tissue Development Endoplasmic Reticulum Tubular Network Pancreas Development Regulation Of Activin Receptor Signaling Pathway Protein Serine/threonine/tyrosine Kinase Activity Endothelial Cell Differentiation Activin Receptor Signaling Pathway Growth Factor Binding Artery Development Insulin Secretion Gastrulation Negative Regulation Of Cold-induced Thermogenesis Organ Growth Negative Regulation Of Ossification Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Blood Vessel Remodeling Negative Regulation Of Macroautophagy Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Regulation Of Multicellular Organismal Development Positive Regulation Of Ossification Mesoderm Development Vasculature Development Receptor Tyrosine Kinase Binding Peptide Hormone Secretion Positive Regulation Of Osteoblast Differentiation Post-embryonic Development Roof Of Mouth Development Regulation Of Bone Mineralization Intracellular Iron Ion Homeostasis Odontogenesis Of Dentin-containing Tooth
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