RNF41 and SRR

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		RNF41	SRR
Description		ring finger protein 41	serine racemase
Image
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Tubular Network	Cytoplasm Cytosol Neuronal Cell Body Apical Part Of Cell
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Enzyme Binding Protein Domain Specific Binding Receptor Tyrosine Kinase Binding Small GTPase Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Magnesium Ion Binding Catalytic Activity L-serine Ammonia-lyase Activity Calcium Ion Binding Protein Binding ATP Binding D-serine Ammonia-lyase Activity Glycine Binding Lyase Activity Isomerase Activity Threonine Racemase Activity PDZ Domain Binding Pyridoxal Phosphate Binding Serine Racemase Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Polyubiquitination Autophagy Apoptotic Process Negative Regulation Of Cell Population Proliferation Proteasomal Protein Catabolic Process Protein Ubiquitination Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Protein Catabolic Process Protein Autoubiquitination Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Mitophagy Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Amino Acid Metabolic Process L-serine Metabolic Process Serine Family Amino Acid Metabolic Process Response To Xenobiotic Stimulus Response To Lipopolysaccharide Pyruvate Biosynthetic Process D-serine Metabolic Process D-serine Biosynthetic Process Response To Ketamine
Pathways		Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation	Serine metabolism
Drugs			Pyridoxal phosphate Serine
Diseases
GWAS		Asthma ( 31619474) Height ( 34054925)	Aortic root size ( 19584346) Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Coronary heart disease ( 21378990) Metabolite levels (5-HIAA) ( 23319000) Schizophrenia ( 25056061 29483656 30285260) Type 2 diabetes ( 20174558)
Interacting Genes		39 interacting genes: ADRB2 AIRIM AP2S1 APP ARL6IP4 BIRC6 CLEC9A ERBB3 ERBB4 IRS4 KDM3B LEPR LZTS2 MAGEL2 MARK2 MEOX2 MNAT1 MTNR1A MTNR1B MTURN N4BP3 RAD23A RFC4 RNF166 RRM2B SRR TCEANC TRIM32 TRIM8 TSG101 TTC1 UBASH3A UBASH3B UBE2D3 UBE2K UBE2U UBE2Z USP8 ZAP70	3 interacting genes: AKT1 APP RNF41
Entrez ID		10193	63826
HPRD ID		11520	10451
Ensembl ID		ENSG00000181852	ENSG00000167720
Uniprot IDs		F8VSB6 Q9H4P4	Q3ZK31 Q9GZT4
PDB IDs		2FZP 2GWF	3L6B 3L6R 5X2L 6SLH 6ZSP 6ZUJ 7NBC 7NBD 7NBF 7NBG 7NBH
Enriched GO Terms of Interacting Partners?		Ubiquitin Conjugating Enzyme Activity Receptor Complex Protein Polyubiquitination Neuregulin Receptor Activity Protein Ubiquitination Melatonin Receptor Activity Post-translational Protein Modification Positive Regulation Of Amyloid Fibril Formation Protein Modification By Small Protein Conjugation Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Free Ubiquitin Chain Polymerization Protein Modification Process Negative Regulation Of Signal Transduction Amacrine Cell Differentiation Negative Regulation Of Cell Communication Macromolecule Metabolic Process Negative Regulation Of Signaling Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Calcium-mediated Signaling Axon Development Regulation Of Viral Process Ubiquitin-protein Transferase Activity Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Suppression Of Viral Release By Host Regulation Of Amyloid Fibril Formation Protein K63-linked Ubiquitination	Positive Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Enzyme Binding Response To Nerve Growth Factor Negative Regulation Of Macroautophagy Regulation Of Protein Catabolic Process Positive Regulation Of Nitric Oxide Metabolic Process Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Catabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Lymphocyte Migration Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cell Activation Regulation Of Response To Endoplasmic Reticulum Stress Apoptotic Process Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Cell Migration Programmed Cell Death Negative Regulation Of Autophagy Cell Death Regulation Of TRNA Methylation Regulation Of Generation Of Precursor Metabolites And Energy Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Postsynapse Organization Regulation Of Cell Motility Regulation Of Mononuclear Cell Migration Regulation Of Locomotion Regulation Of Protein Localization To Nucleus Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Cellular Response To Metal Ion Negative Regulation Of Protein Localization To Lysosome Acetylcholine Receptor Activator Activity Lipoprotein Particle Positive Regulation Of Protein Import Interleukin-3 Receptor Binding Positive Regulation Of Proteolysis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Regulation Of Leukocyte Migration Mammalian Oogenesis Stage Regulation Of Intrinsic Apoptotic Signaling Pathway
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