RNF41 and BIRC6

Number of citations of the paper that reports this interaction (PMID 15314180)
33

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study)

		RNF41	BIRC6
Gene Name		ring finger protein 41, E3 ubiquitin protein ligase	baculoviral IAP repeat containing 6
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Spindle Pole Endosome Trans-Golgi Network Microtubule Organizing Center Membrane Midbody
	Molecular Function	Ubiquitin-protein Transferase Activity Erythropoietin Receptor Binding Interleukin-3 Receptor Binding Protein Binding Zinc Ion Binding Acid-amino Acid Ligase Activity Ral GTPase Binding Protein Tag Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Ligase Activity
	Biological Process	Protein Polyubiquitination Autophagy Negative Regulation Of Cell Proliferation Proteasomal Protein Catabolic Process Negative Regulation Of Cell Migration Regulation Of MAPK Cascade Regulation Of Lymphocyte Differentiation Regulation Of Myeloid Cell Differentiation Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Autoubiquitination Regulation Of Protein Kinase B Signaling Extrinsic Apoptotic Signaling Pathway Regulation Of Establishment Of Cell Polarity Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process	Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Positive Regulation Of Cell Proliferation Negative Regulation Of Endopeptidase Activity Protein Ubiquitination Regulation Of Cytokinesis Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Cell Division Labyrinthine Layer Development Spongiotrophoblast Layer Development Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Signaling by ERBB2 Downregulation of ERBB2:ERBB3 signaling Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: ADRB2 APP ARL6IP4 ASB6 BIRC6 C1orf109 ERBB3 ERBB4 HOMER2 ISCA2 LEPR LZTS2 MARK2 MNAT1 RFC4 RNF166 TRIM32 TRIM8 TSG101 TTC1 UBE2D3 UBE2K UBE2U UBE2Z USP8 VPS52	19 interactors: BIRC5 CASP3 CASP7 CASP8 CASP9 CDK1 CSNK2A1 DIABLO EXOC3 EXOC4 HTRA2 MAP2K1 PLK1 RAB8A RNF41 UBC UBE2D1 USP8 VAV2
Entrez ID		10193	57448
HPRD ID		11520	05731
Ensembl ID			ENSG00000115760
Uniprot IDs		Q9H4P4	Q9NR09
PDB IDs		2FZP 2GWF	3CEG
Enriched GO Terms of Interacting Partners?		Cellular Protein Modification Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Metabolic Process Protein Polyubiquitination Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Catabolic Process Apoptotic Process Programmed Cell Death Regulation Of Viral Transcription Cell Death Death Cellular Response To Stimulus Negative Regulation Of Viral Release From Host Cell Regulation Of Kinase Activity Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Viral Transcription Response To Stress Regulation Of Viral Release From Host Cell Catabolic Process Response To Stimulus Cellular Metabolic Process Regulation Of Growth Regulation Of Signaling Cell Cycle Process Regulation Of Cell Proliferation Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Regulation Of Viral Process Regulation Of Protein Phosphorylation Signal Transduction Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Kinase Activity Mitotic Cell Cycle Cell Division Transcription-coupled Nucleotide-excision Repair Negative Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction	Regulation Of Proteolysis Positive Regulation Of Proteolysis Apoptotic Process Programmed Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Cell Death Apoptotic Signaling Pathway Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Regulation Of Catalytic Activity Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Endopeptidase Activity Positive Regulation Of Cysteine-type Endopeptidase Activity Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Endopeptidase Activity Mitotic Cell Cycle Process Positive Regulation Of Peptidase Activity Negative Regulation Of Cell Cycle TRIF-dependent Toll-like Receptor Signaling Pathway Intracellular Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Protein Metabolic Process Toll-like Receptor 3 Signaling Pathway Mitotic Cell Cycle Proteolysis Positive Regulation Of Cellular Metabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Cellular Macromolecule Catabolic Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Response To Growth Factor Positive Regulation Of Cell Death Protein Catabolic Process Zymogen Activation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		aforementioned balanced cytokine destabilizes determines deubiquitylating dub e3 ectodomain ectopic escrt explains finger identifies indirectly internalization lif lysosomal matches reciprocal recycling redistributes shedding sorted stabilizes steady trafficking ubiquitylates usp8	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Difference) ?		aforementioned balanced cytokine destabilizes determines deubiquitylating dub e3 ectodomain ectopic escrt explains finger identifies indirectly internalization lif lysosomal matches reciprocal recycling redistributes shedding sorted stabilizes steady trafficking ubiquitylates usp8	alt carcinogenesis consequences demonstate encode facilitated facilitates hcc hepatocellular hepatoma iaps immunoblot immunochemical indicative interacted interference knockdown lentivirus mechanistic nude overexpressed partly proognostic remarkably reversed sensitized silencing sorafenib xenograft
Tagcloud (Intersection) ?